Tara Aghaloo

University of California, Los Angeles

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Sotirios Tetradis

University of California, Los Angeles

Olga Bezouglaia

University of California, Los Angeles

Min Lee

University of California, Los Angeles

Benjamin M. Wu

University of Maryland, College Park

Peter K. Moy

University of California, Los Angeles

Danny Hadaya

University of California, Los Angeles

Flávia Q. Pirih

University of California, Los Angeles

Sarah Dry

University of California, Los Angeles

Soyon Kim

University of California, Los Angeles

Akrivoula Soundia

Trios Health

Cooperative Institutions

University of California, Los Angeles

233

Pioneer (United States)

153

National Medical Research Center of Dentistry and Maxillofacial Surgery

111

Harvard University

University of Michigan–Ann Arbor

American Academy of Orthopaedic Surgeons

Faculty of 1000 (United States)

University of Pennsylvania

University of Pittsburgh

University of Southern California

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Site Preservation and Ridge Augmentation

Elsevier eBooks (2016)

Joan Pi‐Anfruns Tara Aghaloo

10.1016/b978-1-4557-5328-4.00020-x

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Citations (0)

Antiresorptive-Type and Discontinuation-Timing Affect ONJ Burden

Journal of Dental Research (2021)

Danny Hadaya Akrivoula Soundia Ioannis Gkouveris Olga Bezouglaia Sarah Dry

Osteonecrosis of the jaws (ONJ), a severe side effect of antiresorptive medications, is characterized by exposed, nonhealing bone in the oral cavity. Treatment options for ONJ range from management of symptomology to surgical resection of the affected area. Antiresorptive discontinuation, often termed a "drug holiday," has been used for managing ONJ patients. Antiresorptives can be discontinued prior to oral surgical procedures, such as tooth extraction, to prevent ONJ development or in patients with established ONJ to accelerate healing. Here, our objective was to test these clinical scenarios using the potent bisphosphonate, zoledronic acid (ZA), and the denosumab surrogate for rodents, OPG-Fc, in a rat model of ONJ. Animals were pretreated with antiresorptives or saline, after which we induced ONJ using periapical disease and tooth extraction. In our first experimental design, antiresorptives were discontinued 1 wk prior to tooth extraction, and animals were evaluated 4 wk later for clinical, radiographic, and histologic features of ONJ. In the second experiment, ONJ was established and antiresorptives were discontinued for 4 wk. Discontinuation of OPG-Fc, but not ZA, prior to tooth extraction ameliorated subsequent ONJ development. In contrast, discontinuation of either ZA or OPG-Fc in rats with established ONJ did not lead to ONJ resolution. In conclusion, our findings suggest that antiresorptive discontinuation is dependent on both the type of antiresorptive and the timing of discontinuation.

Discontinuation

Denosumab

Zoledronic Acid

Dental extraction

Drug holiday

10.1177/0022034520986804

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Citations (13)

Nell-1 Enhances Bone Regeneration in a Rat Critical-Sized Femoral Segmental Defect Model

Plastic & Reconstructive Surgery (2011)

Wei‐Ming Li Janette N. Zara Ronald K. Siu Min Lee Tara Aghaloo

Effective regeneration of bone is critical for fracture repair and incorporation and healing of bone grafts used during orthopedic, dental, and craniofacial reconstructions. Nel-like molecule-1 (Nell-1) is a secreted protein identified from prematurely fused cranial sutures of craniosynostosis patients that has been found to specifically stimulate osteogenic cell differentiation and bone formation. To test the in vivo osteoinductive capacity of Nell-1, a critical-sized femoral segmental defect model in athymic rats was used.A 6-mm defect, which predictably leads to nonunion if left untreated, was created in the left femur of each rat. Three treatment groups (n = 8 each) were created consisting of rats treated with (1) 1.5 mg/ml Nell-1, (2) 0.6 mg/ml Nell-1, and (3) phosphate-buffered saline only as a Nell-free control. Phosphate-buffered saline or Nell-1 was mixed with demineralized bone matrix as a carrier before implantation. All animals were euthanized 12 weeks after surgery, and bone regeneration was evaluated using radiographic, three-dimensional micro-computed tomographic, and histologic analysis.Both Nell-1-treated groups had significantly greater bone formation compared with the Nell-free group, with bone volume increasing with increasing Nell-1 concentration.Nell-1 in a demineralized bone matrix carrier can significantly improve bone regeneration in a critical-sized femoral segmental defect in a dose-dependent manner. The results of this study demonstrate that Nell-1 is a potent osteospecific growth factor that warrants further investigation. Results also support the potential application of Nell-1 as a bone graft substitute in multiple clinical scenarios involving repair of critical bone loss when autograft bone is limited or unavailable.

Demineralized bone matrix

Femoral fracture

X-ray microtomography

10.1097/prs.0b013e3181fed5ae

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Citations (62)

Ghost Cell Odontogenic Carcinoma: A Case Report and Literature Review

The Laryngoscope (2022)

Morcos Nakhla Phillip Q. Richards Jessa E. Miller David Afework Daniel Manzoor

Ghost cell odontogenic carcinoma (GCOC) is an exceptionally rare malignant odontogenic neoplasm with a significant potential for aggressive growth. Although the literature on this tumor is limited, its high recurrence rates suggest that early and multimodal intervention may be beneficial. This study reports a case of GCOC of the mandible that was successfully treated with surgical resection, reconstruction, and radiation. A comprehensive literature review was performed, and the relevant genomic and histopathological characteristics of this malignancy were determined. Laryngoscope , 133:830–833, 2023

Mandible (arthropod mouthpart)

Neoplasm

10.1002/lary.30521

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Citations (1)

The osteoinductive properties of Nell-1 in a rat spinal fusion model

The Spine Journal (2006)

Steven S. Lu Xinli Zhang Chia Soo Tiffany Hsu Antonia Passarelli di Napoli

Demineralized bone matrix

RUNX2

10.1016/j.spinee.2006.04.020

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Citations (115)

Radiographic predictors of bone exposure in patients with stage 0 medication-related osteonecrosis of the jaws

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology (2018)

Akrivoula Soundia Danny Hadaya Sanjay M. Mallya Tara Aghaloo Sotirios Tetradis

Periosteal reaction

10.1016/j.oooo.2018.08.005

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Citations (32)

Resonance Frequency Analysis of Sinus Augmentation by Osteotome Sinus Floor Elevation and Lateral Window Technique

Journal of Oral and Maxillofacial Surgery (2015)

Sarav Patel David Lee Kyle Shiffler Tara Aghaloo Peter K. Moy

Implant stability quotient

Osteotome

Resonance frequency analysis

Sinus (botany)

10.1016/j.joms.2015.04.020

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Citations (13)

Proceedings of the American Association of Oral and Maxillofacial Surgeons 2015 Research Summit

Journal of Oral and Maxillofacial Surgery (2015)

Joseph E. Cillo David L. Basi Zachary S. Peacock Tara Aghaloo Gary F. Bouloux

Summit

Specialty

Dental research

10.1016/j.joms.2015.11.029

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Citations (7)

Adverse effects of hyperlipidemia on bone regeneration and strength

Journal of Bone and Mineral Research (2011)

Flávia Q. Pirih Jinxiu Lu Fei Ye Olga Bezouglaia Elisa Atti

Abstract Hyperlipidemia increases the risk for generation of lipid oxidation products, which accumulate in the subendothelial spaces of vasculature and bone. Atherogenic high-fat diets increase serum levels of oxidized lipids, which are known to attenuate osteogenesis in culture and to promote bone loss in mice. In this study, we investigated whether oxidized lipids affect bone regeneration and mechanical strength. Wild-type (WT) and hyperlipidemic (Ldlr−/−) mice were placed on a high-fat (HF) diet for 13 weeks. Bilateral cranial defects were introduced on each side of the sagittal suture, and 5 weeks postsurgery on the respective diets, the repair/regeneration of cranial bones and mechanical properties of femoral bones were assessed. MicroCT and histological analyses demonstrated that bone regeneration was significantly impaired by the HF diet in WT and Ldlr−/− mice. In femoral bone, cortical bone volume fraction (bone volume [BV]/tissue volume [TV]) was significantly reduced, whereas cortical porosity was increased by the HF diet in Ldlr−/− but not in WT mice. Femoral bone strength and stiffness, measured by three-point bending analysis, were significantly reduced by the HF diet in Ldlr−/−, but not in WT mice. Serum analysis showed that the HF diet significantly increased levels of parathyroid hormone, tumor necrosis factor (TNF)-α, calcium, and phosphorus, whereas it reduced procollagen type I N-terminal propeptide, a serum marker of bone formation, in Ldlr−/−, but not in WT mice. The serum level of carboxyl-terminal collagen crosslinks, a marker for bone resorption, was also 1.7-fold greater in Ldlr−/− mice. These findings suggest that hyperlipidemia induces secondary hyperparathyroidism and impairs bone regeneration and mechanical strength. © 2012 American Society for Bone and Mineral Research

Hyperlipidemia

10.1002/jbmr.541

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Citations (117)

Oxygen-Enriched Osteoinductive Nanoerythrocytes Augment Cell Survival and Osteogenic Differentiation for Bone Regeneration

Chemistry of Materials (2022)

Chung‐Sung Lee Jiabing Fan Hee Sook Hwang Chen Chen Soyon Kim

Despite three-dimensional biomaterial scaffolds emerging for facilitating tissue remodeling and recovery in tissue engineering, the scaffolds with an insufficient oxygen supply are limited by various concerns, such as their retention, localization, survival, and lineage fate control of post-transplantation of stem cells. Herein, we report oxygen-enriched osteoinductive nanoerythrocytes as a facile biomimetic platform for bone formation, combining the biocompatibility of natural red blood cell membranes with the oxygen-carrying perfluorocarbons and the osteoinductive oxysterols. The resulting nanoerythrocytes exhibit a high capacity for oxygen delivery, improving cell survival and proliferation and mitigating hypoxic stress in cell-laden hydrogels as a three-dimensional biomaterial device in vitro and in vivo. Notably, the introduction of oxysterols incites the osteoinductive activity for the differentiation of progenitor cells toward osteogenic lineage through the positive regulation of Hedgehog signaling and in vivo reossification activity against a nonhealing calvarial defect. Given the beneficial properties of the assembled parts in a facile single system, this bioactive and biomimetic nanodelivery system can have the potential to address desired needs in the biomaterial scaffolds for cell delivery and bone tissue engineering.

Biomaterial

Biocompatibility

10.1021/acs.chemmater.2c00376

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Citations (4)