Dietmar Thurnher

Medical University of Graz

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Boban M. Erović

Medical University of Vienna

Gregor Heiduschka

Medical University of Vienna

Matthäus Ch. Grasl

Medical University of Vienna

Piero Lercher

Medical University of Vienna

Markus Brunner

Universitätsklinikum Erlangen

Dritan Turhani

Danube Private University

Edgar Selzer

Medical University of Vienna

Sven Schneider

Medical University of Vienna

Ulana Kotowski

Medical University of Vienna

Rudolf Seemann

Medical University of Vienna

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Medical University of Vienna

205

Vienna General Hospital

University of Vienna

Medical University of Graz

Comprehensive Cancer Center Vienna

Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde

University of Graz

Graz University Hospital

Heidelberg University

Ludwig-Maximilians-Universität München

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P25 Effect of bioactive compounds of zingiber officinale roscoe on head and neck tumor cell lines

Oral Oncology (2015)

Ulana Kotowski Gregor Heiduschka Sven Schneider E. Enzenhofer Isabella Stanisz

Zingiber officinale

Clonogenic assay

10.1016/j.oraloncology.2015.02.073

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Citations (2)

Rhinogener Kopfschmerz

Dietmar Thurnher Matthäus Ch. Grasl Boban M. Erović Piero Lercher

akute Entzündung einer oder mehrerer Nasennebenhöhlen meist rhinogener Ursache

10.1007/978-3-211-88985-5_24

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Halsschwellung

Dietmar Thurnher Matthäus Ch. Grasl Boban M. Erović Piero Lercher

akute Entzündung der regionalen Lymphknoten mit einem Krankheitsverlauf von < 4 Wochen

10.1007/978-3-211-88985-5_9

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RCAS-1 Serum and Tumor Levels in Head and Neck Squamous Cell Carcinoma

European Surgical Research (2010)

Markus Brunner Boban M. Erović Gregor Heiduschka Sven Schneider Johannes Pammer

RCAS-1 is a transmembrane protein that is involved in the evasion of host immune surveillance by tumor cells. It has been found to be a valuable prognostic and diagnostic marker in a number of different malignancies. The objective of the study was to analyze the potency of RCAS-1 as a biomarker in the serum of patients with head and neck squamous cell carcinoma (HNSCC).ELISA was performed with prospectively collected serum samples from 60 patients with HNSCC (taken at the time of diagnosis, after 3 and 12 months) and from 31 healthy controls. To correlate serum levels with RCAS-1 expression in the tumor, immunohistochemical staining of RCAS-1 was done using a tissue microarray.Surprisingly, median sRCAS-1 levels were basically identical between tumor patients and controls. Interestingly, patients with low RCAS-1 values at the time of diagnosis had better disease-free survival. 62% of tumor samples expressed RCAS-1 but we could not demonstrate a correlation between protein expression and serum levels.This study was the first to correlate RCAS-1 levels in the serum and in the tumor of the same patients. RCAS-1 seems to have prognostic properties although larger studies will be necessary to fully evaluate its role in HNSCC.

Tissue microarray

10.1159/000314613

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Halsschmerzen

Dietmar Thurnher Matthäus Ch. Grasl Boban M. Erović Piero Lercher

(Angina = "Enge des Isthmus faucium" = Schlundenge), akute Gaumenmandelentzündung akute bakterielle Entzündung der Gaumenmandel, obwohl der Begriff eigentlich alle "Tonsillen" des Waldeyer-Rachenringes einschließt

10.1007/978-3-211-88985-5_8

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Formveränderung und Trauma von Nase und Ohr Nasenpframidenfraktur

Dietmar Thurnher Matthäus Ch. Grasl Boban M. Erović Piero Lercher

10.1007/978-3-211-88985-5_4

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Merkel Cell Carcinoma: Interdisciplinary Management of a Rare Disease

Journal of Skin Cancer (2013)

Sven Schneider Dietmar Thurnher Boban M. Erović

Background. The goal of this paper is to review contemporary multidisciplinary treatment with reference to Merkel cell carcinoma. Management of this rare but highly aggressive skin cancer is a complex undertaking that necessitates an understanding of its etiology, epidemiology, clinical presentation, and the coordinated work of several clinical specializations. Recent Findings. The contemporary literature employs a multidisciplinary approach to achieve the best patient's treatment. Conclusion. This paper presents an algorithm for contemporary management for the rare and aggressive Merkel cell carcinoma. Multidisciplinary approach in a tumor center provides high-quality care for patients with Merkel cell carcinoma.

10.1155/2013/189342

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Citations (19)

Allergie

Dietmar Thurnher Matthäus Ch. Grasl Boban M. Erović Piero Lercher

Im Jahre 1902 wurde erstmals die anaphylaktische Reaktion durch Portier und Richet beschrieben. Sie haben einem Hund ein Toxin einer Seeanemone aus dem Mittelmeer gespritzt und beobachteten, wie es zuerst zur Hypersalivation, Atemschwierigkeiten, Paralyse und schließlich zum Tod kam. In den frühen 1960ern wurden die Hypersensitivitätsreaktionen nach Coombs und Gell in vier Typen eingeteilt:

Hypersalivation

10.1007/978-3-211-88985-5_34

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Early effects of cigarette smoke extract on human oral keratinocytes and carcinogenesis in head and neck squamous cell carcinoma

Head & Neck (2020)

Elisabeth Foki Katharina Gangl Veronika Kranebitter Verena Niederberger‐Leppin Julia Eckl‐Dorna

Abstract Background Cigarette smoking is a major risk factor for head and neck squamous cell carcinoma. Still, the effect of cigarette smoke on the molecular level is unclear. The aim of the present study was to investigate the early effects of cigarette smoke on carcinogenesis of head and neck squamous cell carcinoma. Methods Human oral keratinocytes were exposed for 1 week to standardized cigarette smoke extract, and subsequently RT‐quantitative PCR array was performed. Protein expression of dysregulated genes was determined by immunohistochemistry in tissue samples of oral squamous cell carcinoma, oral leukoplakia, and tonsil mucosa. Results RT‐PCR revealed upregulation of ITGA‐2 and MMP‐1, whereas TEK receptor tyrosine kinase was downregulated in human oral keratinocytes. ITGA‐2 and MMP‐1 were significantly overexpressed in tissue samples of oral squamous cell carcinoma in comparison to normal mucosa ( P <.01 in all experiments). Conclusion Upregulation of ITGA‐2 and MMP‐1 induced by cigarette smoke contributes significantly to oral carcinogenesis.

Oral mucosa

Epidermoid carcinoma

10.1002/hed.26247

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Citations (7)

Überexpression von β1-Integrin in oralen Keratinozyten korreliert mit deren hohen Proliferationskapazität

Wiener klinische Wochenschrift (2007)

Elisabeth Stein Karin Blaimauer Sieglinde Bauer Boban M. Erović Dritan Turhani

Oral mucosa

10.1007/s00508-007-0783-6

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Citations (7)