Chyng‐Yann Shiue

National Taiwan University Hospital

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Alfred P. Wolf

Kraftanlagen (Germany)

Joanna S. Fowler

Brookhaven National Laboratory

Ya-Yao Huang

National Taiwan University

Kuo‐Hsing Ma

National Defense Medical Center

Robert MacGregor

Hoover Institution

Kai‐Yuan Tzen

National Taiwan University Hospital

Cheng‐Yi Cheng

Tri-Service General Hospital

Grace G. Shiue

Brookhaven National Laboratory

Ta-Kai Chou

Tri-Service General Hospital

Carroll D. Arnett

Brookhaven National Laboratory

Cooperative Institutions

National Defense Medical Center

National Taiwan University

Brookhaven National Laboratory

Tri-Service General Hospital

National Taiwan University Hospital

National Yang Ming Chiao Tung University

University of Pennsylvania

Brookhaven College

Changhua Christian Hospital

New York University

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Study on the neuroprotective effect of fluoxetine against MDMA-induced neurotoxicity on the serotonin transporter in rat brain using micro-PET

NeuroImage (2009)

I‐Hsun Li Wen-Sheng Huang Chyng‐Yann Shiue Ya-Yao Huang Ren-Shyan Liu

MDMA

Neurotoxicity

Immunostaining

Serotonin reuptake inhibitor

10.1016/j.neuroimage.2009.07.072

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Citations (52)

Potential Approaches for Beta Cell Imaging with PET and SPECT

Current Medicinal Chemistry - Immunology Endocrine & Metabolic Agents (2004)

Chyng‐Yann Shiue Alfred Schmitz Ralf Schirrmacher Grace G. Shiue Abass Alavi

Diabetes mellitus is a major public health problem and comprises a heterogeneous group of disorders characterized by high blood glucose levels. Two major types of diabetes mellitus have been defined: type 1 and type 2. Pancreatic beta-cell mass (BCM) is markedly reduced in type 1 diabetes due to selective autoimmune destruction of insulin-producing beta-cells of the pancreas. To date, the accurate assessment of pancreatic beta-cells in human diabetes has been limited to autopsy studies, which usually suffer from inadequate clinical information. Thus, the development of noninvasive technique to assess the state of viability of beta-cells in vivo during the silent phase of prediabetes or after islet transplantation will be useful for clinical intervention. A number of imaging modalities have been proposed to evaluate BCM including cellular imaging, MRI, and nuclear imaging. However, none of these modalities has yet been successfully applied to human studies. In this article, we review the development and the feasibility of using radiolabeled metals, monoclonal antibody, monosaccharides, sulfonylurea receptor ligands and gene expression reporter probes as radiotracers for imaging BCM with PET and SPECT. Keywords: beta-cell imaging, sulfonylurea receptors, glyburide, repaglinide, f-18, c-11, pet

Repaglinide

Molecular Imaging

Imaging agent

10.2174/1568013043357293

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Citations (7)

No-carrier-added (NCA) (±)-N-(3-[18F]fluoropropyl)-N-normetazocine-Synthesis and PET studies in a baboon

International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology (1987)

Chyng‐Yann Shiue Ren‐Rui Teng Lan-Qin Bai Alfred P. Wolf Carroll D. Arnett

Radioligand

Radiosynthesis

Opiate

PET Imaging

Specific activity

Biodistribution

10.1016/0883-2897(87)90141-3

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Citations (3)

A practical and pyrogen-free preparation of ¹¹C-L-methionine in a good manufacturing practice-compliant approach

Journal of Medical Sciences (2017)

DanielH Shen Kang‐Po Li Ming‐Kuan Hu Cheng‐Yi Cheng Li-Fan Hsu

Aims: ¹¹C-L-methionine, an amino acid tracer used to delineate certain tumor tissues, has proven to be a prevailing nonfluorodeoxyglucose positron emission tomography (PET) radiopharmaceutical. We intended to prepare ¹¹C-L-methionine by following modified synthetic strategies at a rebuilt working area to meet the PET drug current good manufacturing practice (cGMP) and Pharmaceutical Inspection Co-operation Scheme (PIC/S) regulations. Furthermore, we overcame the problem of pyrogen cross-contamination using a cleaner and more efficient program. Material and Methods: The task of upgrading air filtration equipment was integrated with the set of Web-Based Building Automation system (WebCTRL^®). ¹¹C-L-methionine synthesis was carried out in accordance with redesigned methods to meet the requirements of PET drug cGMP. The product quality was tested by a series of quality control tests and was found to be satisfactory. Depyrogenation was carried out by three different methods with different flow rates and flushing durations. The results were examined through limulus amebocyte lysate clotting test. Results: The level of air cleanliness in each section meets the PIC/S GMP standards after the reconstructions. Moreover, after delicate modifications, the radiochemical yield of ¹¹C-L-methionine was 36.20% ± 3.59% (based on ¹¹C-CH₃I, n = 7), which is about 10% higher than the average former yield. Besides, the used depyrogenation methods could wipe the bioburden off within 8 h. Conclusions: The modifications done not only offer a good production environment but also protect the products from contamination. The modified approaches in both ¹¹C-L-methionine production and depyrogenation resulted in prominent progress in stability and efficiency as well.

Contamination control

10.4103/1011-4564.200735

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Masthead

Radiochimica Acta (1990)

G. Stöcklin Zeev B. Alfassi Giancarlo Angelini Sherifa M. Abu‐Bakr Fulvio Cacace

10.1524/ract.1990.50.12.masthead

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Gas‐liquid chromatographic determination of relative amounts of 2‐deoxy‐2‐flouro‐D‐glucose and 2‐deoxy‐2‐fluoro‐D‐mannose synthesized from various methods

Journal of Labelled Compounds and Radiopharmaceuticals (1985)

Chyng‐Yann Shiue Joanna S. Fowler Alfred P. Wolf David Alexoff Robert MacGregor

Abstract A column (6 ft × 1/8 in) containing 4% SE‐30 + 6% OV‐210 on Chromosorb W‐HP 80/100 mesh was employed to determine the relative amounts of 2‐deoxy‐2‐fluoro‐D‐glucose (2‐FDG) and 2‐deoxy‐2‐fluoro‐D‐mannose (2‐FPM) synthesized using various methods. The 2‐FDG synthesized from published methods contains 4–56% of 2‐FDM.

D-Glucose

10.1002/jlcr.2580220511

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Citations (29)

An automated synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) for imaging serotonin transporters

Applied Radiation and Isotopes (2007)

Chi‐Jiun Peng Ya-Yao Huang Wen-Sheng Huang Chyng‐Yann Shiue

Benzylamine

Radioligand

10.1016/j.apradiso.2007.11.009

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Citations (29)

ChemInform Abstract: RK. VON ALPHA,BETA-DIBROM-OXIMEN UND VERWANDTEN VERBINDUNGEN MIT NITROSYLCHLORID

Chemischer Informationsdienst (1973)

Edward G. Bozzi Chyng‐Yann Shiue Leallyn B. Clapp

Abstract Bei der Behandlung mit Nitrosylchlorid erhält man aus den Dibrom‐oximen (Ia) unter milden Bedingungen die Substitutionsprodukte (II), während bei längerer Reaktionsdauer oder unter energischeren Bedingungen die N‐Nitro‐ Derivate (III) gebildet werden.

10.1002/chin.197317255

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Syntheses of (/sup 18/F) aryl fluorides by fluorination of aryltrimethylsilanes or arylpentafluorosilicates with (/sup 18/F)F/sub 2/ or (/sup 18/F)CH/sub 3/CO/sub 2/F

Journal of Nuclear Medicine (1984)

M. Speranza Chyng‐Yann Shiue Alfred P. Wolf D. Scott Wilbur

F-18 Aryl fluorides are the important intermediates for the syntheses of F-18 labeled radiopharmaceuticals. F-18 Labeled aryl fluorides have been synthesized either from (/sup 18/F)F/sub 2/ or (/sup 18/F)fluoride. The authors report here the syntheses of (/sup 18/F)aryl fluorides by fluorination of aryltrimethylsilanes (1) or arylpentaflurorsilicates (2) with (/sup 18/F)F/sub 2/ or (/sup 18/F)CH/sub 3/CO/sub 2/F. Fluorination of compounds (1) with either (/sup 18/F)F/sub 2/ or (/sup 18/F)CH/sub 3/CO/sub 2/F give the corresponding aryl fluorides (3) and the aryltrimethylsilyl fluorides (4) in 2-10% yields depending on the reaction conditions. Compounds (2) and (3) can easily be separate by HPLC or GLC. Treatment of compounds (4) with HClO/sub 4/-MeOH (1:1) give the corresponding desilylated compounds (3underscore). Fluorination of compounds (2) with (/sup 18/F)CH/sub 3/CO/sub 2/F give the corresponding aryl fluorides (3) in 10-20% yield. The yields of compounds (3) and (4) depend on the reaction conditions. Lower temperature (-76/sup 0/C in freon vs 25/sup 0/C in CH/sub 3/CO/sub 2/H) favors the formation of aryl fluorides, (/sup 18/F)F/sub 2/ gives a better yield of aryl fluorides than with (/sup 18/F)CH/sub 3/CO/sub 2/F, and the electron-withdrawing groups are in favor of aryl fluoride formations. This method thus provides an alternative route to F-18more » labeled radiopharmaceuticals such as p-/sup 18/F)fluorohippuric acid which is otherwise difficult to prepare, and other F-18 labeled neuroleptics.« less

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A new synthesis of 2-deoxy-d-arabino-hexose

Carbohydrate Research (1979)

Chyng‐Yann Shiue Robert MacGregor Robert E. Lade Chung-N. Wan Alfred P. Wolf

Synthon

Hydrogen cyanide

Heteroatom

Cyanation

10.1016/s0008-6215(00)84787-4

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Citations (15)