Allison Ledoux

University of Liège

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Michel Frédérich

University of Liège

Olivia Jansen

University of Liège

Lúcia Mamede

University of Liège

Pauline Desdemoustier

University of Liège

Alembert Tiabou Tchinda

Institut de Recherches Médicales et d’Etudes des Plantes Médicinales

Joëlle Quetin‐Leclercq

UCLouvain

Olivier Bonnet

University of Liège

Luc Angenot

University of Liège

Carla Hamann

University of Liège

Ewa Cieckiewicz

University of Liège

Cooperative Institutions

University of Liège

Centre National de la Recherche Scientifique

Inserm

Institut de Chimie des Substances Naturelles

Pharmac

Écologie Marine Tropicale des Océans Pacifique et Indien

Université Libre de Bruxelles

UCLouvain

Observatoire des Sciences de l'Univers de la Réunion

Laboratoire de Chimie

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Cytotoxic Metabolites from Calophyllum tacamahaca Willd.: Isolation and Detection through Feature-Based Molecular Networking

Metabolites (2023)

Élise Gerometta Gaëtan Herbette Elnur Garayev Arnaud Marvilliers Jean‐Valère Naubron

Isocaloteysmannic acid (1), a new chromanone, was isolated from the leaf extract of the medicinal species Calophyllum tacamahaca Willd. along with 13 known metabolites belonging to the families of biflavonoids (2), xanthones (3-5, 10), coumarins (6-8) and triterpenes (9, 11-14). The structure of the new compound was characterized based on nuclear magnetic resonance (NMR), high-resolution electrospray mass spectrometry (HRESIMS), ultraviolet (UV) and infrared (IR) data. Its absolute configuration was assigned through electronic circular dichroism (ECD) measurements. Compound (1) showed a moderate cytotoxicity against HepG2 and HT29 cell lines, with IC50 values of 19.65 and 25.68 µg/mL, respectively, according to the Red Dye method. Compounds 7, 8 and 10-13 exhibited a potent cytotoxic activity, with IC50 values ranging from 2.44 to 15.38 µg/mL, against one or both cell lines. A feature-based molecular networking (FBMN) approach led to the detection of a large amount of xanthones in the leaves extract, and particularly analogues of the cytotoxic isolated xanthone pyranojacareubin (10).

Xanthone

Terpene

Biflavonoids

10.3390/metabo13050582

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Affinity capillary electrophoresis as a tool for the discovery of new antimalarial natural compounds

Marie Gils Allison Ledoux Clara Davoine Pauline Desdemoustier Marie-Elodie Clain

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Phytochemical investigation and biological activities from Lantana rhodesiensis Moldenke.

Fatimata Nea Boni Michel Bitchi Manon Genva Allison Ledoux Alembert Tiabou Tchinda

Phytochemical

Lantana

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CCDC 1405062: Experimental Crystal Structure Determination

The Cambridge Structural Database (2015)

Nada Marquise Floris Chevallier Ekhlas Nassar Michel Frédérich Allison Ledoux

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/cc1j52lc

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Unveiling antiplasmodial alkaloids from a cumulative collection of Strychnos extracts by multi-informative molecular networks

Frontiers in Molecular Biosciences (2022)

Olivier Bonnet Mehdi A. Beniddir Pierre Champy Gilles Degotte Lúcia Mamede

Malaria, a disease known for thousands of years and caused by parasites of the Plasmodium genus, continues to cause many deaths throughout the world today, particularly due to the emergence of parasite resistance to the current therapeutic arsenal. Plants of the Strychnos genus, remarkable due to their multiple traditional uses as well as their alkaloid content, are promising candidates to develop new antimalarial treatments. Indeed, previous research on this plant group has shown promising (≤ 5 µg/ml) or good (between 5 and 15 µg/ml) antiplasmodial activities. Using the chloroquine-sensitive strain of Plasmodium falciparum (3D7), and artemisinin as positive control, a screening of antiplasmodial activities from 43 crude methanolic extracts from 28 species of the Strychnos genus was carried out in three independent assays. A total of 12 extracts had good (6 extracts) or promising (6 extracts) antiplasmodial activities. These results allowed both to confirm known activities but also to detect new ones. These extracts were then analyzed by HPLC-ESI(+)-Q/TOF, and the processed MS/MS data allowed to generate a molecular network in which the antiplasmodial activities were implemented as metadata. The exploration of the molecular network revealed the presence of alkaloids still unknown, and potentially active against malaria, in particular alkaloids close to usambarensine and its derivatives. This study shows that the emergence of molecular networking offers new leads for identifications of alkaloids from the Strychnos genus. The presence of unknown alkaloids potentially active against malaria confirms all the interest to continue in studying the Strychnos genus. Bioassay- and mass-guided fractionations as well as various dereplication tools would allow to identify and characterize these interesting alkaloids further.

Strychnos

10.3389/fmolb.2022.967012

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[Nystagmography with eyes open or closed during the caloric test].

PubMed (1967)

Allison Ledoux Demanez Jp

Caloric theory

Caloric test

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Citations (2)