Yuanbao Zhan

Southeast University

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Lu Yu

Jilin University

Xiangwei Zhao

Southeast University

Yu Wan

Harbin Institute of Technology

Qinyu Ge

Southeast University

Dianhuai Meng

Nanjing Medical University

Yu Wan

Jiangsu Normal University

Yan Huang

Southeast University

Xi Yang

Zhejiang University

Yanhui Wan

Shenzhen Second People's Hospital

Qingjiang Sun

State Key Laboratory of Digital Medical Engineering

Cooperative Institutions

Southeast University

State Key Laboratory of Digital Medical Engineering

Nanjing Medical University

Chinese Academy of Sciences

Zhejiang University

BioElectronics (United States)

Ministry of Education of the People's Republic of China

Jilin University

First Hospital of Jilin University

Southeast University

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A nanostructured lateral flow immunoassay strip combined with Au@SiO₂ SERS nanotags for multiplex biomarker detection

Materials Advances (2023)

Geng Zhu Yuanbao Zhan Lu Yu Fei Zheng Yu Wan

A nanostructured lateral flow immunoassay strip with Au@SiO 2 SERS nanotags was constructed. This is the first time nanostructured T line and SERS-LFA has been combined, which has great potential for early non-invasive detection of AD biomarkers in blood.

Multiplex

10.1039/d3ma00595j

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Ultrasensitive detection of multiple Alzheimer's disease biomarkers by SERS-LFA

The Analyst (2022)

Yuanbao Zhan Ruihua Fei Lu Yu Yu Wan Xuming Wu

Alzheimer's disease (AD) is one of the top public health crises in the 21st century, especially in an aging society. Early diagnosis, prevention, and intervention can significantly reduce the risk of AD. Detection of multiple AD biomarkers in blood is an effective strategy and has drawn more and more attention in recent years. However, the concentration of AD biomarkers is very low, therefore, point-of-care testing (POCT) techniques are needed for sensitive detection. Herein, a lateral flow assay, based on Surface-enhanced Raman scattering nanotags (SERS-LFA), is proposed for the simultaneous quantification of multiple AD biomarkers including Amyloid-beta 42, Amyloid-beta 40, tau proteins, and neurofilament light chain. The limit of detection for four AD biomarkers is 138.1, 191.2, 257.1, and 309.1 fg mL-1, respectively, which are two orders of magnitude lower than their concentrations in blood. Compared with the existing detection technology, SERS-LFA has the advantages of high specificity, high sensitivity, low cost, multiple detection, and rapid detection. Therefore, SERS-LFA has a broad application prospect in the early diagnosis and monitoring of AD in the future.

Point-of-Care Testing

10.1039/d2an00717g

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Citations (23)