Shafiq U. Ahmed

University of Sunderland

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Anthony J. Chalmers

University of Glasgow

Ross Carruthers

Beatson West of Scotland Cancer Centre

Emilia Peuhu

Turku University Hospital

Jukka Westermarck

University of Turku

Oxana V. Denisova

University of Turku

Mikael Jumppanen

University of Helsinki

Pirjo Laakkonen

University of Helsinki

John Eriksson

Åbo Akademi University

Olayinka Raheem

Tampere University

Hannu Haapasalo

Tampere University Hospital

Cooperative Institutions

Newcastle University

Cancer Research UK

University of Glasgow

Cancer Research UK Scotland Institute

University of Oxford

University of Newcastle Australia

University of Sunderland

University of Cambridge

Newcastle upon Tyne Hospital

Glasgow Life

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Supplementary Table S2 from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells

Amanpreet Kaur Oxana V. Denisova Xi Qiao Mikael Jumppanen Emilia Peuhu

List of indolocarbazole staurosporine analogues, their primary target proteins, and status in the clinical trials for the indicated diseases.

Staurosporine

Protein kinase inhibitor

10.1158/0008-5472.22413783.v1

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Supplementary Table S4 from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells

Amanpreet Kaur Oxana V. Denisova Xi Qiao Mikael Jumppanen Emilia Peuhu

List of PME-1 regulated PP2A B-subunits and their known interactor proteins.

Protein kinase inhibitor

10.1158/0008-5472.22413777.v1

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Supplementary Figure S6 from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells

Amanpreet Kaur Oxana V. Denisova Xi Qiao Mikael Jumppanen Emilia Peuhu

PME-1 and HDAC4 expression can predict glioma patient response to kinase inhibitors. Supplementary figure related to Figure 6.

10.1158/0008-5472.22413795.v1

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Supplementary Table S3 from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells

Amanpreet Kaur Oxana V. Denisova Xi Qiao Mikael Jumppanen Emilia Peuhu

Structure-activity relationship (SAR) analysis of STS derivatives to identify active synthetic lethality in PME-1 depleted cells.

Synthetic Lethality

10.1158/0008-5472.22413780

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Status of Animal Health with Emphasis of Blue Tongue Virus Disease in Kalat Region, Balochistan

Pak-Euro Journal of Medical and Life Sciences (2019)

Shafiq U. Ahmed Muhammad Shafee Abdul Razzaq Muhammad Rahim Niazi Abdul Wahid

Bluetongue is non contagious vector borne viral disease of small ruminants. It transmits by biting of culicoids midges and causes severe economic losses to animal owner in term of high morbidity, decreased production and impaired reproduction. Balochistan, being largest province of the country have scattered population in far remote areas. About 70% of the provincial population rely upon livestock rearing for their livelihood. Kalat is largest division of the province that stretches from Kalat city upto Lasbella including Khuzdar, Kharan and Awaran. It is located on main RCD route that will ultimately boost the animal marketing and their easy access to main market. Although different vaccines are practiced throughout the province but no such vaccine is available against BTV in the country. That’s why animals are facing problems of some undiagnosed diseases. This review provides necessary information about disease in the region. It is need of the time to educate farmer and strict vigilance may be practiced for proper and timely vaccination of all animals to curtail deadliest diseases in the region.

Animal health

10.31580/pjmls.v2i2.1144

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Attitude of women of NWFP towards antenatal care.

PubMed (2002)

Anwar Sultana Shafiq U. Ahmed

A safe motherhood initiative is a global effort to reduce maternal mortality and morbidity. This aims to ensure improvement in the quality and safety of lives of women through adoption of health and non-health strategies. Antenatal care is a branch of preventive medicine dealing with prevention and early detection of pregnancy disorders. It is the key to modern obstetrics.It was a descriptive type of study to find out the attitude of the women towards utilization of antenatal care facility at a newly commissioned hospital, Hayatabad Medical Complex, Peshawar, Pakistan in the first year of its working.We recorded 980 patients. All of them were married. Monthly attendance showed increasing trend. In this study 72.44% of the women were of 25-35 year of age while 11.42% were teenager. Multiparity was recorded in 38.97% and 12.14% had more then nine pregnancies. Six hundred and fifty patients were living near the hospital. 2.24% patients visited more than six times and 63.26% had one visit only, with the rest visiting for 2-5 times. Thirty patients had medical disorders. Obstetrical diseases were detected in 194 patients. Pregnancy losses contributed to 146 women and 3 women had more then 6 losses. 254 women selected hospital delivery. Out of then 160 women were booked in the 3rd trimester. Caesarean section rate among those women was 16.4%.The conclusion drawn was that the women living near the hospital used the facility. Antenatal care should be provided to the women at the doorstep of their house. There is a system of lady health workers that should be expanded to cover all areas. Basic health units must be fully equipped and staffed. Communication system should be improved. There is a need to include health education in the curricula of primary education.

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Supplementary Figure S4 from Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells

Ross Carruthers Shafiq U. Ahmed Shaliny Ramachandran Karen Strathdee Kathreena M. Kurian

Supplementary Figure S4 shows additional images of immunofluorescent staining in GBM intracranial xenografts.

Radioresistance

Replication

10.1158/0008-5472.22426303

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Supplementary Figure S2 from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells

Amanpreet Kaur Oxana V. Denisova Xi Qiao Mikael Jumppanen Emilia Peuhu

Clinically relevant kinase inhibitors display synthetic lethality in PME-1 depleted glioma cells. Supplementary figure related to Figure 2.

Synthetic Lethality

10.1158/0008-5472.22413807

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High throughput screening campaigns for the development of novel therapeutics in Glioblastomas

Shafiq U. Ahmed

High-Throughput Screening

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Data from Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells

Shafiq U. Ahmed Ross Carruthers Lesley Gilmour Salih Yildirim Colin K. W. Watts

<div>AbstractGlioblastoma is the most common form of primary brain tumor in adults and is essentially incurable. Despite aggressive treatment regimens centered on radiotherapy, tumor recurrence is inevitable and is thought to be driven by glioblastoma stem-like cells (GSC) that are highly radioresistant. DNA damage response pathways are key determinants of radiosensitivity but the extent to which these overlapping and parallel signaling components contribute to GSC radioresistance is unclear. Using a panel of primary patient-derived glioblastoma cell lines, we confirmed by clonogenic survival assays that GSCs were significantly more radioresistant than paired tumor bulk populations. DNA damage response targets ATM, ATR, CHK1, and PARP1 were upregulated in GSCs, and CHK1 was preferentially activated following irradiation. Consequently, GSCs exhibit rapid G2–M cell-cycle checkpoint activation and enhanced DNA repair. Inhibition of CHK1 or ATR successfully abrogated G2–M checkpoint function, leading to increased mitotic catastrophe and a modest increase in radiation sensitivity. Inhibition of ATM had dual effects on cell-cycle checkpoint regulation and DNA repair that were associated with greater radiosensitizing effects on GSCs than inhibition of CHK1, ATR, or PARP alone. Combined inhibition of PARP and ATR resulted in a profound radiosensitization of GSCs, which was of greater magnitude than in bulk populations and also exceeded the effect of ATM inhibition. These data demonstrate that multiple, parallel DNA damage signaling pathways contribute to GSC radioresistance and that combined inhibition of cell-cycle checkpoint and DNA repair targets provides the most effective means to overcome radioresistance of GSC. Cancer Res; 75(20); 4416–28. ©2015 AACR.</div>

DNA Damage Repair

10.1158/0008-5472.c.6506739.v1

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