Makoto Mizutani

Handa City Hospital

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Histochemical Study of Rabbit Masseter Muscle: The effect of the alteration of food on the muscle fibers

Oral Medicine & Pathology (2001)

Takefumi Negoro Kanmon Ito Takumi Morita Katsunari Hiraba Makoto Mizutani

The purpose of the present study is to investigate the effect of a fine-grained food on the composition and development of the masseter fibers in the rabbits. Masseter fibers were classified as one of three types based on their levels of staining for myofibrillar ATP ase. In Type I (slow) fibers, the diameter and ratio of the fiber was most remarkably decreased by the fine-grained diet. The ratio of type IIa and IIb fibers in the fine-grained diet subjects were increased. The diameter of all fibers in the deep region showed significant decrease. In the superficial region, the diameter of Type I and IIa fibers decreased; however, the diameter of Type IIb increased. These findings suggest that the histochemical characteristics of the masseter muscle are reflected in size and composition of the muscle fibers by decreasing the masticatory loads.

Myofibril

Muscle fibre

Fiber type

Mastication

10.3353/omp.6.65

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Citations (7)

Studies on Agglutinability and Hemolytic Activity of Various Lectins on Red Blood Cells in Chickens

Nihon Chikusan Gakkaiho (1983)

Makoto Mizutani Hidehiko Umezawa Shigemi Kuramasu

44種のマメ科植物を含む159種の植物の抽出液について,ブラックミノルカ種,白色レグホーン種,フアヨウミ種およびニューハンプシャー種を含む10羽のニワトリの赤血球に対する凝集性および溶血性を試験した.その結果,抽出液は次の6群に区分された.第1群;すべての個体の赤血球を凝集も溶血もしなかったもの78種,第2群;すべての個体の赤血球を凝集し,溶血しなかったもの40種,第3群;すべての個体の赤血球を凝集せず,溶血したもの11種,第4群;すべての個体の赤血球を凝集し,かつ溶血したもの3種,第5群;一部の個体の赤血球を凝集するが,他の個体の赤血球は凝集せず,すべての個体の赤血球を溶血しなかったもの24種,第6群;一部の個体の赤血球を凝集するが,他の個体の赤血球は凝集せず,すべての個体の赤血球を溶血したもの3種,ニワトリの個体間差を識別しえた第5群および第6群については試験個体数をふやして凝集性を調査した結果,凝集性の違いから次の4群に区分された.a群;従来の動物血液型と同様,雌雄の別なく陽性•陰性個体を区分したもの.これに属するものはラッカセイを含む15種であった.b群;Hi (Ph)凝集原と反応していると思れたもの.これに属するものはエンドウを含む8種であった.C群;a,b両群の性質をもっているもの.すなわち,雌雄の別なく陽性•陰性個体を区分し,なおかつ雌においては産卵に伴いHi (Ph)凝集原と異なる凝集原の出現により凝集性が変化するもの.これに属するものはジャガイモ,チューリップの2種であった.d群;Hi (Ph)凝集原あるいはC群の凝集原とも果なる凝集原が産卵に伴い出現し,凝集性が変化するもの.これに属するものはニラ1種であった.

10.2508/chikusan.54.9_525

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Thyrotrophin in the pars tuberalis triggers photoperiodic response

Nature (2008)

Nobuhiro Nakao Hiroko Ono Takashi Yamamura Tsubasa Anraku Tsuyoshi Takagi

Pars tuberalis

DIO2

10.1038/nature06738

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Citations (487)

Decomposition Behavior of PCDDs/PCDFs in the Process of Sulfuration of Heavy Metals in Fly Ash.

KAGAKU KOGAKU RONBUNSHU (2003)

Kayo Sawada Hitoki Matsuda Makoto Mizutani

飛灰をアスファルトと硫黄，水酸化ナトリウムとともに加熱混線することによる飛灰中重金属の硫化物固定化処理過程において，飛灰中のダイオキシン類の分解が可能であることが明らかとなった．ダイオキシン類の分解は脱塩素化によって進行し，飛灰100g（ダイオキシン類含有量14,490ng/g，毒性当量34.3ngTEQ/g）に対し，アスファルト2.5g，硫黄5.3g，水酸化ナトリウム8.0g，混練温度593K，混練時間1時間の条件下で，ほぼ100%の分解率が得られた．

10.1252/kakoronbunshu.29.309

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Citations (3)

Studies of “St” Agglutinogen in Chickens Reacted with Potato PHA

Kachiku ketsuekigata kenkyu joho (1979)

Makoto Mizutani Masaharu Koike Hidehiko Umezawa Shigemi Kuramasu

10.5924/abgri1972.1979.24

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Citations (1)

Inherited muscular disorder in mutant Japanese quail (Coturnix coturnix japonica): an immunohistochemical study

Journal of Comparative Pathology (1996)

Shinya Tanaka I.S. Braga Takashi Kimura K. Ochiai C. Itakura

Coturnix coturnix

Sarcoplasm

Coturnix

10.1016/s0021-9975(96)80036-3

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Citations (3)

Scierai ectasia associated with hereditary retinal dysplasia in a mutant strain of Japanese quail (Coturnix coturnix japonica)

Avian Pathology (1997)

Kazumoto Shibuya Tetsuo Nunoya M. Tajima Makoto Mizutani

Ocular defects and age-related lesions in mutant (GUB strain) Japanese quail (Coturnix coturnix japonica), phenotypically characterised by silver plumage, are described. Grossly, a circular area of hypopigmentation in the posterior retina with thinning of the subjacent sciera was observed in all GUB quails. As the birds matured, the thinned sciera progressed to scierai ectasia. Histologically, the sciera at the ectatic area consisted of an outer fibrous layer and was devoid of the inner cartilaginous shell. Atypical differentiation and duplication of the retina with absence of the choroid was common at the ectatic area. The retina, choroid, ciliary body and iris were all poorly pigmented. With increasing age, the ectatic area became cystic, and the duplicated retina degenerated and atrophied. In addition, there were mononuclear cell infiltration in the stroma of the iris and ciliary body, anterior and posterior synechiae, cataract and/or glaucoma in aged GUB quails. These findings suggest that posterior scierai ectasia in the GUB strain of Japanese quails may have developed secondarily to a congenital structural defect of the posterior portion of sciera associating with general ocular defects.

Coturnix coturnix

Choroid

Ectasia

10.1080/03079459708419193

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Citations (3)

Pathological study of Japanese quail embryo with acid α-glucosidase deficiency during early development

Acta Neuropathologica (1996)

Sachiko Miyagawa‐Tomita M. Morishima Mitsuru Nakazawa Makoto Mizutani Tateki Kikuchi

10.1007/s004010050515

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Citations (12)

The Journal of Animal Genetics (2000)

Eun Jun Lee Hideyuki Mannen Makoto Mizutani Soichi TSUJI

10.5924/abgri2000.28.95

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Citations (0)

Analyses of Beta-1 Syntrophin, Syndecan 2 and Gem GTPase as Candidates for Chicken Muscular Dystrophy

EXPERIMENTAL ANIMALS (2003)

K. Yoshizawa Kyoko Inaba Hideyuki Mannen Tateki Kikuchi Makoto Mizutani

Despite intensive studies of muscular dystrophy of chicken, the responsible gene has not yet been identified. Our recent studies mapped the genetic locus for abnormal muscle (AM) of chicken with muscular dystrophy to chromosome 2q using the Kobe University (KU) resource family, and revealed the chromosome region where the AM gene is located has conserved synteny to human chromosome 8q11-24.3, where the beta-1 syntrophin (SNTB1), syndecan 2 (SDC2) and Gem GTPase (GEM) genes are located. It is reasonable to assume those genes might be candidates for the AM gene. In this study, we cloned and sequenced the chicken SNTB1, SDC2 and GEM genes, and identified sequence polymorphisms between parents of the resource family. The polymorphisms were genotyped to place these genes on the chicken linkage map. The AM gene of chromosome 2q was mapped 130 cM from the distal end, and closely linked to calbindin 1 (CALB1). SNTB1 and SDC2 genes were mapped 88.5 cM distal and 27.6 cM distal from the AM gene, while the GEM gene was mapped 18.5 cM distal from the AM gene and 9.1 cM proximal from SDC2. Orthologues of SNTB1, SDC2 and GEM were syntenic to human chromosome 8q. SNTB1, SDC2 and GEM did not correspond to the AM gene locus, suggesting it is unlikely they are related to chicken muscular dystrophy. However, this result also suggests that the genes located in the proximal region of the CALB1 gene on human chromosome 8q are possible candidates for this disease.

Synteny

Genetic linkage

Gene map

Gene cluster

10.1538/expanim.52.391

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Citations (16)