T R Emerson

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C. M. B. Pare

St Bartholomew's Hospital

P Turner

National Hospital for Neurology and Neurosurgery

RS Ehsanullah

St Bartholomew's Hospital

J Wadsworth

Imperial College London

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St Bartholomew's Hospital

National Hospital for Neurology and Neurosurgery

University College London

Florida Atlantic University

Centre hospitalier de l'Université Laval

Wilfrid Laurier University

Pharmac

Advisory Board Company (United States)

Iowa City Public Library

Lancet Laboratories

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Platelet uptake of 5-hydroxytryptamine and dopamine and its relationship to mood in normal subjects.

PubMed (1980)

T R Emerson RS Ehsanullah C. M. B. Pare P Turner J Wadsworth

Platelet uptake of the amines 5-hydroxytryptamine (5-HT) and dopamine has been found to be lower in depressed than in normal subjects. In the latter the values were more scattered. To discover whether this scatter was due to mild depression or predisposition to depression, 50 normal subjects whose amine uptake had been studied were asked to complete a questionnaire on symptoms and history of depression. No significant correlation between decreased amine uptake and answers to the questionnaire was found, but a correlation of minor significance (r=0.33; P less than 0.025) was found between increased number of potentially depressing life events and increased 5-HT uptake, contrary to what might have been expected. The scatter of values for amine uptake does not appear to be related to mood, or to personal or family history of depression.

Depression

Biogenic amine

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