Y Tsuchiya

Ajinomoto (United States)

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[Intracavitary high dose rate afterloading irradiation of inoperable malignant bile duct obstruction].

PubMed (1986)

Jun Itami Kenji Saegusa Y Tsuchiya Takashi Mamiya Tetsutaro Miyoshi

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Citations (6)

Chylous ascites secondary to liver cirrhosis with special reference to lymphangiography and lipoprotein analysis of chylous ascites.

Nihon Naika Gakkai Zasshi (1985)

Humio Sakurai Shoichi Tomono Y Tsuchiya Hideo Takeuchi Hiroshige Itakura

肝硬変以外に腫瘍や炎症などの要因なく,乳び腹水を続発した症例を経験したので報告する.症例は50才の男性で,既往に昭和30年肺結核による肺切除術後の輸血後肝炎がある.昭和56年11月,腹水貯留を主訴として入院した.症状および検査成績より肝硬変の非代償期と診断し,安静,減塩高蛋白食および利尿薬投与にて腹水は,一時消失したが,入院12週頃より再貯留し,利尿薬に反応せず,腹水は乳様混濁を呈してきた.腹水中のトリグリセライドは著しく増加し,血清値より高値で,トリグリセライド/コレステロール比は高く,超遠心法を用いた蛋白分析では比重1.006以下の分画が著増していた.リンパ管造影では,乳び槽近くでの不完全閉塞を思わせる所見が得られたが,剖検ではリンパ路の異常は認められなかつた.乳び腹水中の比重1.006以下のリポ蛋白分画のpolyacrylamide gel electrophoresisによるアポリポ蛋白分析では,腸管由来のアポB48とともに肝由来のアポB100,アポB26を認めた.また乳び腹水中のアポA定量では,アポAI 10.6mg/dl,アポAII 1.3mg/dlの値を得,アポAI/AII比は正常血清と比べ上昇していた.われわれの知る限り,本症例は肝硬変に続発した乳び腹水のアポリポ蛋白分析を行なつた最初の報告例である.

Chylous Ascites

Chyle

Ascitic fluid

10.2169/naika.74.40

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Citations (1)

Effect of a New Hypoglycemic Agent, A-4166 ((-)-N-(trans-4-Isopropylcyclohexanecarbonyl)-D-phenylalanine), on Postprandial Blood Glucose Excursion: Comparison with Voglibose and Glibenclamide.

Biological and Pharmaceutical Bulletin (1997)

Takao Ikenoue Kouichirou Okazaki Shoji Fujitani Y Tsuchiya Megumi Akiyoshi

(-)-N-(trans-4-Isopropylcyclohexanecarbonyl)-D-phenylalanine (A-4166) is a new nonsulfonylurea hypoglycemic agent that lowers blood glucose by stimulating insulin release. In the present study, we examined the effects of A-4166, voglibose (an α-glucosidase inhibitor), and glibenclamide (a sulfonylurea) on the postprandial glycemic increase in rats with or without diabetes millitus. Oral administration of A-4166 (25-100 mg/kg) dose-dependently decreased blood glucose with a rapid onset and short duration in normal rats. On the other hand, glibenclamide (1-4 mg/kg) showed a slower onset of its hypoglycemic action, and voglibose (0.2 mg/kg) had no effect. In the case of postprandial glucose excursion, the carbohydrate-induced increase in blood glucose was reduced by oral administration of either A-4166 or voglibose without causing sustained hypoglycemia in both normal and neonatal streptozotocin-induced diabetic rats. However, the efficacy of voglibose varied with the type of carbohydrate load. Glibenclamide produced a prolonged decrease in blood glucose without any appreciable effect on the initial glucose excursion. After sucrose loading, plasma insulin levels during the initial 1 h were significantly higher in A-4166-treated rats than in control rats, while voglibose completely inhibited the insulin response to sucrose. In glibenclamide-treated rats, an augmented insulin response was not seen. In conclusion, unlike other hypoglycemic agents, A-4166 suppresses postprandial glucose excursions by stimulating the early phase of insulin secretion.

10.1248/bpb.20.354

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Citations (44)

Studies on post-transfusion hepatitis

Kitakantou igaku/Kitakantō Igaku (1964)

Tadashi Maekawa Takuo Shirakura Takehisa Wada Yoshiro Sugai Isamu Nagashima

(1) Post-transfusion hepatitis occurred in eleven paients out of eighty-two in-patients received transfusion with whole blood or blood plasma during recent five years.(2) Incidence of the hepatitis was related to the total amount of blood transfused. Posttransfusion hepatitis occurred more frequently among the patients transfused larger amount of bood.(3) There was no significant difference between the incidence of post-transfusion hepatitis in the patients transfused with fresh blood and that with stored blood only.(4) Changes in the results of hepatic function tests were followed during the course of the hepatitis in these patients. Serum GPT level was higher than SGOT at the onset of jaundice and recovery of SGPT level to normal ranges was delayed as compared with that of SGOT. Increase in serum iron level with decrease in UIBC was observed in these cases.

Hepatic function

Blood units

10.2974/kmj1951.14.235

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Citations (1)

REPORT OF 2 CASES WITH LEUKEMIA COMPLICATING ILEUS

Nihon Naika Gakkai Zasshi (1965)

R Shigiya Tadashi Maekawa Y Tsuchiya Takuo Shirakura T Kamiyama

白血病は全身疾患であり,消化管に病変を伴なうことは稀でないにもかかわらず,白血病経過中に11eusを併発した症例の報告は極めて少ない.若者らは,最近かかる2症例を経験した.第1例は23才の男で急性白血病増悪期に腹痛,〓吐等のIleus症状を呈し急速に死亡した.剖検により盲腸に形成された小児手拳大の白血病細胞による腫瘤の潰瘍が穿我して限局性腹膜炎を惹起し,腸係蹄の癒着および腸管麻痺によりIleusが招来されたと判定し得た.第2例は, 48才の女で慢性白血病発病陵4年を経過した症例で,全身衰弱が明らかとなつた時期に,下肢知覚・運動障害,尿閉等の神経症状の発現とともに麻痺性Ileusが出現した. 手術により一時小康状態に入つたが15日目に下血を惹起して死亡した。本例では,腸管の閉塞,癒着等は認められず,回腸と大腸の全般にわたり白血病性小潰瘍と腸壁内神経叢細胞の変性,脳脊髄の神経細胞の変性,末梢神経束の変性等が認められた.

Ileus

10.2169/naika.54.336

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Citations (0)

STUDIES ON THE LEG BLOOD PRESSURE

Nihon Naika Gakkai Zasshi (1973)

Y Tsuchiya

上腕用の血圧計を下腿にまいて足背動脈または後径骨動脈のコロトコフ音を聴診し,血圧を測定し,下腿血圧とした.これを他側の足背動脈直接法,上腕間接法と比較した.上腕間接法との比較は,性・年令・疾患別に検討し,統計処理を行ない,その関係を明らかにした.下腿間接血圧は,足背動脈直接法による血圧と比較的良く一致した。上腕血圧と比較すると,平均値では最大血圧で1.3±15.6mmHg,最小血圧で1.4±14.0mmHg下腿が低かつた.上腕下腿血圧差は性差を認め,最大血圧は女性の下腿血圧がより低い傾向を示した.男性40才台では下腿血圧が上腕より高く,女性では,各年代を通じ上腕に比し下腿血圧が男性のその年代の者より一層低く, 40才台から70才台にかけ男女共次第に上腕下腿差が下腿の低い方向に大きくなつてゆく傾向を示した.悪性高血圧症,尿毒症では明らかに下腿血圧が上腕血圧を上まわつたが,良性高血圧症,高窒素血症を伴わない慢性腎炎では,この傾向が認められなかつた.

10.2169/naika.62.129

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A CASE OF SARCOIDOSIS WITH HEART FAILURE, HYPERCALCEMIA AND URINARY CALCULUS

Kitakantou igaku/Kitakantō Igaku (1985)

Hisao Kumakura Norio Kanazawa Yoshihiro Tajima Masami Kogure Syuichi Kurihara

A fifty-year-old man was admitted to the hospital because of nocturnal dyspnea. Physical examination showed moist rales, an enlarged liver and edema in lower extremities. X-ray films of the chest revealed lung edema, cardiomegaly and bilateral hilar lymphadenopathy. An electrocardiogram showed right bundle branch block and multiple ventricular premature beats. An echocardiogram and a left ventriculography disclosed decreased ejection fraction and cardiac output. The serum calcium level, angiotensin converting enzyme and serum 1, 25 dihydroxyvitamin D were elevated. An ultra-sound examination and a urogram revealed renal and ureteral calculus. The diagnosis was made on the evidence of epiteloid cell granulomas and giant cells in the biopsy specimen of the lung. Although the sarcoidosis has been known to be associated with hypercalcemia and urinary calculus, this association has been reported only in eight cases in Japan.

10.2974/kmj1951.35.553

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Citations (0)

[Carcinoma of the hilar bile ducts].

PubMed (1995)

Toshio Tsuyuguchi H Saisho Y Tsuchiya M Ohto

Bile Duct Carcinoma

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Primary intestinal lymphangiectasia with epileptic episodes as the initial symptom of the disease.

Nihon Naika Gakkai Zasshi (1988)

Norihiro KATOU Hiroshi Tsukada Tomio Ohno Rikurou Hayashi Shoichi Tomono

症例は18才,男性.頻回に繰り返すてんかん発作の精査治療目的にて入院した.神経学的にはChvostek徴候およびTrousseau徴候を認めた.脳波上てんかん波が確認され,カルシウム,ビタミンD,の低下を認めた.血清化学検査上,総蛋白質3.0g/dlと著明な低値を示し, α1-アンチトリプシンクリアランスおよび125I-PVP漏出試験の結果より,蛋白喪失性胃腸症が確認された.リンパ管造影および小腸生検で腸リンパ管拡張症の所見が得られ,他に基礎疾患を認めないことから,原発性腸リンパ管拡張症と診断した.てんかん発作は本症に伴う低カルシウム血症が引金になったと思われるが,これまでてんかんを併発した本症の報告はない.

10.2169/naika.77.1037

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Citations (1)

Diagnosis of hepatolithiasis.

PubMed (1984)

M Ohto Kazumi Kimura Y Tsuchiya H Saisho S Matsutani

Hepatolithiasis

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Citations (12)