Guiyun Wang

Shandong Xiehe University

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George H. Greeley

The University of Texas Medical Branch at Galveston

Ella W. Englander

The University of Texas Medical Branch at Galveston

Song Han

LG (South Korea)

Qi Xiang

Jinan University

Heung‐Man Lee

Korea University Medical Center

Börje S. Andersson

The University of Texas MD Anderson Cancer Center

Qirong Chen

Central South University

Richard E. Champlin

The University of Texas MD Anderson Cancer Center

Qi Xiang

Jinan University

Hong Li

Institute of Physics

Cooperative Institutions

Inserm

Centre National de la Recherche Scientifique

Chinese Academy of Sciences

Northeast Normal University

Chinese Academy of Medical Sciences & Peking Union Medical College

Université de Rouen Normandie

National Institutes of Health

Wenzhou Medical University

Central South University

University of Michigan–Ann Arbor

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Adjuvant effect of a novel water-soluble polysaccharide isolated from the stem of Physalis alkekengi L. var. francheti (Mast.) Makino

Journal of Medicinal Plants Research (2011)

Dongjie Shang Lili Zhang Shuying Han Guiyun Wang

Water-soluble polysacchride (WSP) was isolated and purified from the mature stem ofPhysalis alkekengi L. var. francheti (Mast.) Makino, which is a traditional Chinese medicine herb. Gas chromatography (GC) analysis indicated that WSP was an acid heteropolysaccharide, which was composed of Rha, Ara, Gal, Glc and GalA in molar ratio of 2.6 : 1.0 : 6.5 : 3.5 : 2.4. More importantly, adjuvant activity of WSP was evaluated in ICR mice in present study. Male ICR mice were immunized subcutaneously with ovalbumin (OVA) alone, OVA/WSP, OVA/QuilA, and saline two times at 14-day interval. The mice were sacrificed two weeks after the last immunization to analyze antibody titers in serum. It was observed that WSP significantly enhanced OVA-specific antibody titers (IgG, IgG1, IgG2b) in serum when compared with OVA-injected mice (P<0.05 or P<0.01). Thus, WSP could be considered as a promising adjuvant eliciting both Th1 and Th2 responses to improve the efficacy of vaccine. Key words: Herbal medicine, Physalis alkekengi L., polysaccharide, adjuvant.

Physalis

10.5897/jmpr.9000044

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Citations (6)

山東省における在宅介護需要の現状【JST・京大機械翻訳】

Zhongguo Laonianxue Zazhi (2016)

Guiyun Wang Wang Ruowei Yang Qingai

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[Mitochondrial membrane potential at HL-60 cell apoptosis induced by cytarabine].

Journal of Experimental Hematology (2007)

Lili Sun Li-Rong Sun Guiyun Wang

Rhodamine 123

Rhodamine

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Citations (2)

Three‐in‐One: Molecular Engineering of D–A–π–A Featured Type I and Type II Near‐Infrared AIE Photosensitizers for Efficient Photodynamic Cancer Therapy and Bacteria Killing

Small (2024)

Yun‐Yun Quan Tingting Pan Zhongda Zhang Shihua Wang Guiyun Wang

Abstract Bacterial infections are closely correlated with the genesis and progression of cancer, and the elimination of cancer‐related bacteria may improve the efficacy of cancer treatment. However, the combinatorial therapy that utilizes two or more chemodrugs will increase potential adverse effects. Image‐guided photodynamic therapy is a highly precise and potential therapy to treat tumor and microbial infections. Herein, four donor–acceptor–π‐bridge–acceptor (D–A–π–A) featured near‐infrared (NIR) aggregation‐induced emission luminogens (AIEgens) ( TQTPy , TPQTPy , TQTC , and TPQTC ) with type I and type II reaction oxygen species (ROS) generation capabilities are synthesized. Notably, TQTPy shows mitochondria targeted capacity, the best ROS production efficiency, long‐term tumor retention capacity, and more importantly, the three‐in‐one fluorescence imaging guided therapy against both tumor and microbial infections. Both in vitro and in vivo results validate that TQTPy performs well in practical biomedical application in terms of NIR‐fluorescence imaging‐guided photodynamic cancer diagnosis and treatment. Moreover, the amphiphilic and positively charged TQTPy is able to specific and ultrafast discrimination and elimination of Gram‐positive (G+) Staphylococcus aureus from Gram‐negative (G−) Escherichia coli and normal cells. This investigation provides an instructive way for the construction of three‐in‐one treatment for image‐guided photodynamic cancer therapy and bacteria elimination.

Cancer Therapy

Fluorescence-lifetime imaging microscopy

10.1002/smll.202402854

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Citations (1)

Mechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: Relevance of p53 and its clinical implications

Experimental Hematology (2013)

Benigno C. Valdez Guiyun Wang David Murray Yago Nieto Yang Li

Clofarabine

Deoxycytidine kinase

Nucleoside analogue

Carmustine

10.1016/j.exphem.2013.04.009

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Citations (16)

Evaluation of immunologic enhancement mediated by a polysaccharide isolated from the fruit of Physalis alkekengi L. var. francheti (Mast.) Makino

Journal of Medicinal Plants Research (2011)

Yonggang Li Shuying Han Zhaohua Hou Yali Liu Jinbo Fang

The study was to investigate the immunologic enhancement mediated by a polysaccharide (designated PPSB) purified from the mature fruits of Physalis alkekengi L. var. francheti (Mast.) Makino. Male ICR mice were immunized subcutaneously with ovalbumin (OVA) alone, OVA/PPSB, OVA/QuilA, and saline two times at 14-day interval. The mice were sacrificed two weeks after the last immunization to analyze humoral and cellular immunity. Delayed-type hypersensitivity (DTH) response was further detected. Moreover, toxicity of PPSB was evaluated by haemolytic activity and acute toxicity assay. The results showed that PPSB significantly enhanced OVA-specific antibody titers (IgG, IgG1, IgG2b) in serum, the concanavalin (ConA), lipopolysaccharide (LPS), OVA-induced splenocyte proliferation, proportions of CD4+ and CD8+ T lymphocytes in spleen, DTH response when compared with OVA-injected mice (P < 0.05 or P < 0.01). Toxicity assay indicated PPSB was non-toxic. Therefore, PPSB mediated both humoral immunity and cellular immunity, and it was non-toxic. Thus, PPSB should be considered as a promising adjuvant eliciting both Th1 and Th2 responses to improve the efficacy of vaccine. Key words: Herbal medicine, polysaccharide, humoral response, cellular response, adjuvant.

Humoral immunity

Physalis

Splenocyte

Cellular immunity

10.5897/jmpr.9000627

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Citations (7)

Protective immune responses against systemic candidiasis mediated by phage-displayed specific epitope of Candida albicans heat shock protein 90 in C57BL/6J mice

Vaccine (2006)

Guiyun Wang Meiyan Sun Jinbo Fang Qiong Yang Haibin Tong

Systemic candidiasis

10.1016/j.vaccine.2006.05.022