Anna Grzywa-Celińska

Medical University of Lublin

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Jerzy Mosiewicz

Medical University of Lublin

Justyna Emeryk-Maksymiuk

Medical University of Lublin

Rafał Celiński

State School of Higher Education in Chełm

Katarzyna Szewczyk

Medical University of Lublin

Adam Krusiński

Medical University of Lublin

Janusz Milanowski

Medical University of Lublin

Katarzyna Szmygin-Milanowska

Medical University of Lublin

Andrzej Prystupa

Medical University of Lublin

Ewa Kurys-Denis

Medical University of Lublin

Jan Siwiec

Medical University of Lublin

Cooperative Institutions

Medical University of Lublin

1 Military Clinical Hospital with Outpatient Clinic

Instytut Medycyny Wsi im. Witolda Chodźki

Lublin Oncology Center

Medical University of Warsaw

Poznan University of Medical Sciences

University of Warsaw

Polish Academy of Sciences

University of Economics and Innovation

Instytut Gruźlicy i Chorób Płuc

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[Diagnosis differential of Klinefelter's syndrome in a 24-year old male hospitalized with with sudden dyspnoea--case report].

PubMed (2009)

Anna Grzywa-Celińska Ewa Rymarz Jerzy Mosiewicz

Klinefelter's syndrome is the most common genetically determined cause of male infertility. It is also connected with higher risk of many diseases such as cardiovascular disorders and malignant tumors as breast cancer and germinal tumors. As a consequence of phenotypic variability, still the majority of cases remains undiagnosed.24 years old male who was admitted to the department because of an episode of sudden resting dyspnoea with the coexisting pain in the retrosternal region and a state of anxiety. Performed examinations did not confirm the diagnosis of heart muscle dysfunction and pulmonary embolism either. However, we noticed the constellation of the specific phenotype features of this patient: high stature, gynecomastia, abdominal obesity, poor hair growth in genital regions. The hormonal tests were performed that allowed to diagnose the hypergonadotropic hypogonadism. Cytogenetic examination revealed the abnormal karyotype of 47,XXY.There are no clear references as to diagnosing the Klinefelter's syndrome. Probably, like in this case report, in the majority of cases the diagnosis is accidental.

Klinefelter syndrome

Gynecomastia

Hypergonadotropic hypogonadism

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Citations (1)

What Remains up to 7 Months after Severe and Moderate Pneumonia in Non-Vaccinated Patients with Long COVID? Results of a CT Study

Journal of Clinical Medicine (2023)

Ewa Kurys-Denis Anna Grzywa-Celińska Katarzyna Podgórska Miłosz Kawa

Background: There is a growing evidence of long-lasting lung changes after COVID-19. Our aim was to assess the degree of lung injury and evaluate the recovery process of 4–7-month-non-vaccinated convalescent patients discharged from hospital after moderate and severe COVID-19 pneumonia, who presented with symptoms of long-COVID. Methods: On control lung CT after mean 5-month recovery period, we classified and determined the prevalence of residual radiological abnormalities in 39 symptomatic patients. To assess the advancement of the persisting changes we used the total severity score (TSS) and the chest CT score and then correlated the results with clinical data. Results and conclusions: On follow-up CT images, 94.9% of patients showed persistent radiological abnormalities. The most frequent changes were ground-glass opacities (74.4%), reticular pattern (64.1%), fibrotic changes (53.8%), nodules (33.3%), bronchiectasis (15.4%), vascular enlargement (10.3%), and cavitation (5.1%). The median TSS score was 4.1 points (interquartile range 3), whereas the median of the chest CT score 5.4 points (interquartile range of 4.5). No significant differences were observed between sex subgroups and between the severe and moderate course groups. There were no association between both CT scores and the severity of the initial disease, indicating that, mean 5 months after the disease, pulmonary abnormalities reduced to a similar stage in both subgroups of severity.

Interquartile range

Ground-glass opacity

10.3390/jcm12165388

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Coronary arteritis as a cause of cardiac rhythm disorders

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Emilia Rymkiewicz Agnieszka Karczewska Beata Lis Barbara Mosiewicz Katarzyna Sołdaj–Bukszyńska

Arteritis

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IgA vasculitis after COVID-19: a case-based review

Rheumatology International (2024)

Dorota Suszek Anna Grzywa-Celińska Justyna Emeryk-Maksymiuk Adam Krusiński Katarzyna Redestowicz

IgA-associated vasculitis (IgAV) known as Henoch - Schönlein purpura (HSP) disease is an inflammatory disorder of small blood vessels. It's the most common type of systemic vasculitis in children which can be associated with the inflammatory process following infections. IgA vasculitis is a rare and poorly understood systemic vasculitis in adults. Coronavirus disease 2019 (COVID-19) has been associated with HSP in both adults and children. A 58-year-old woman was diagnosed with HSP, fulfilling the clinical criteria: palpable purpura, arthritis, hematuria. The disclosure of the HSP disease was preceded by a infection of the respiratory tract. COVID-19 infection was confirmed via the presence of IgM and IgG antibodies. This case indicates the possible role of SARS-CoV-2 in the development of HSP. The clinical course of IgAV in adults appears to be different from pediatric IgAV, especially due to higher risk of renal complications. Symptoms of the disease quickly resolved with low-dose of steroids.

Systemic vasculitis

Purpura (gastropod)

Palpable purpura

Immunoglobulin A

10.1007/s00296-024-05606-4

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Citations (2)

Should statins be applied in patients with hepatic disease? – Discussion based on case report

Medycyna Ogólna i Nauki o Zdrowiu (2010)

Andrzej Prystupa Anna Grzywa-Celińska Jerzy Mosiewicz

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Residential Radon Exposure in Patients with Advanced Lung Cancer in Lublin Region, Poland

International Journal of Environmental Research and Public Health (2022)

Anna Grzywa-Celińska Izabela Chmielewska Adam Krusiński Krzysztof Kozak J. E. Mazur

Exposure to radon is the second most common factor causing lung cancer in smokers and the first among non-smokers. We aimed to measure the impact of the radon exposure on patients with different histological types of advanced lung cancer. The measurement of radon exposure was performed in 102 patients with lung cancer in stage 3B or higher (Poland). There were 78.4% of patients with non-small cell carcinoma and 21.6% of patients with small cell carcinoma. One month radon exposure measurement was performed with trace detectors in order to control whether high radon concentrations (>800 Bq/m3) were found in the homes of patients with cancer diagnosed. Results of the determinations were then compared with the representation of the most common types of lung cancer in the study population. In the analyzed group, the average concentration of radon during the exposure of the detector in the residential premises of the respondents accounted for 69.0 Bq/m3 [37.0–117.0] and had no statistically significant effect on the type of lung cancer developed in patients. The lack of statistical significance may result from the small study group and the accompanying exposure to other harmful components. As the incidence of lung adenocarcinoma is increasing and exposure to tobacco smoke is decreasing, the search for other modifiable causes of lung cancer should be the task in the future.

Tobacco smoke

Radon exposure

10.3390/ijerph19074257

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Citations (5)

Are patients undergoing treatment of hyperlipidaemia with statins the best candidates for early cardiac rehabilitation?

Archives of Medical Science (2011)

Rafał Celiński Anna Grzywa-Celińska Wojciech Myśliński Andrzej Dybała Jerzy Mosiewicz

The role of statins in the primary and secondary prevention of cardiovascular events is well known.An important adverse event associated with statin treatment is myopathy; intensive physical effort in patients treated with statins increases the risk of muscle injury/myopathy.In this article we discuss the benefits and risks associated with statin treatment in patients undergoing cardiac rehabilitation after acute coronary syndromes and/or coronary revascularization procedures.In our opinion, the benefits of the secondary prevention of coronary heart disease achieved with statins seem to outweigh the hazards associated with statin therapy.The careful selection of patients for both treatment with statins and the gradual intensification of physical training in the course of cardiac rehabilitation appears to constitute an important element of the therapeutic approach.

Secondary Prevention

Cardiovascular event

10.5114/aoms.2011.25548

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Citations (1)

Asthma and asthmatic state in everyday medical practice

Medycyna Ogólna i Nauki o Zdrowiu (2014)

Anna Grzywa-Celińska Patrycja Lachowska-Kotowska Andrzej Prystupa Rafał Celiński Michał Kotowski

Medical practice

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‘TB or not TB?’ Problems of differential diagnosis of cutaneous mycobacteriosis and tuberculosis – A Case Study and interdisciplinary discussion

Annals of Agricultural and Environmental Medicine (2015)

Katarzyna Szmygin-Milanowska Anna Grzywa-Celińska Zofia Zwolska Paweł Krawczyk L. Guz

The diagnosis of cutaneous tuberculosis poses a serious challenge due to many skin diseases of different etiology resembling the lesions caused by the TB (tuberculosis) bacillus, and difficulties in confirming the disease. The presented case concerns skin lesions in a hobby aquarist stung in the finger of the left hand by a fish. The resulting inflammatory infiltration was to be cutaneous tuberculosis or mycobacteriosis caused by MOTT (Mycobacterium other than tuberculosis). Laboratory, pathomorphologic, genetic and microbiologic tests of samples obtained from the patient, fish and water in the aquarium gave ambiguous results. A multidisciplinary discussion is presented on the difficulties in the differential diagnosis, problems with a clear interpretation of the results of various conducted tests, and possible ways of transmission of the infection, relevant to the described example.

Cutaneous tuberculosis

Mycobacterium Infections

10.5604/12321966.1196861

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Citations (4)

Coronary arteritis as a cause of cardiac rhythm disorders

Zenodo (CERN European Organization for Nuclear Research) (2017)

Emilia Rymkiewicz Agnieszka Karczewska Beata Lis Barbara Mosiewicz Katarzyna Sołdaj–Bukszyńska

Arteritis

10.5281/zenodo.854838

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