Farbod N. Rahaghi

Beth Israel Deaconess Medical Center

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Co-Authors

Raúl San Jośe Estépar

Brigham and Women's Hospital

George R. Washko

Brigham and Women's Hospital

Pietro Nardelli

Brigham and Women's Hospital

Aaron B. Waxman

Brigham and Women's Hospital

James C. Ross

Brigham and Women's Hospital

Alejandro A. Díaz

Brigham and Women's Hospital

Samuel Y. Ash

Brigham and Women's Hospital

Gonzalo Vegas‐Sánchez‐Ferrero

Brigham and Women's Hospital

R. San José Estépar

Harvard University

Jasleen Minhas

Pulmonary and Allergy Associates

Cooperative Institutions

Brigham and Women's Hospital

212

Harvard University

179

Pulmonary and Critical Care Associates

103

University of Colorado Denver

University of Colorado Anschutz Medical Campus

National Jewish Health

Cleveland Clinic

University of Michigan–Ann Arbor

University of California, San Francisco

University of California, Los Angeles

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Chest Computed Tomography to Improve Phenotyping in Pulmonary Hypertension Associated with COPD

Annals of the American Thoracic Society (2024)

Shelsey W. Johnson Emily S. Wan Raúl San Jośe Estépar Pietro Nardelli Carrie P. Aaron

10.1513/annalsats.202408-878ps

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Citations (0)

Leveraging Artificial Intelligence to Measure Left Atrial Size to Identify Left Heart Disease in Suspected Pulmonary Hypertension

A Ahmad Imran Ahmad Eduardo Garcés Raúl San Jośe Estépar George R. Washko

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4026

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Isolated subsegmental pulmonary embolism identification based on international classification of diseases (ICD)-10 codes and imaging reports

Thrombosis Research (2025)

Sina Rashedi Antoine Bejjani Andetta R. Hunsaker Ayaz Aghayev Candrika D. Khairani

Identification

10.1016/j.thromres.2025.109271

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Is pulmonary arterial hypertension associated with schistosomiasis distinct from pulmonary arterial hypertension associated with portal hypertension?

JHLT Open (2023)

Brian B. Graham Joan F. Hilton Michael H. Lee Rahul Kumar Dara Fonseca Balladares

Pulmonary arterial hypertension associated with schistosomiasis (SchPAH) and pulmonary arterial hypertension associated with portal hypertension (PoPAH) are lung diseases that develop in the presence of liver diseases. However, mechanistic pathways by which the underlying liver conditions and other drivers contribute to the development and progression of PAH are unclear for both etiologies. In turn, these unknowns limit certainty of strategies to prevent, diagnose, and reverse the resultant PAH. Here we consider specific mechanisms that contribute to SchPAH and PoPAH, identifying those that may be shared and those that appear to be unique to each etiology, in the hope that this exploration will both highlight known causal drivers and identify knowledge gaps appropriate for future research. Overall, the key pathophysiologic differences that we identify between SchPAH and PoPAH suggest that they are not variants of a single condition.

Etiology

Pathophysiology of hypertension

Pathophysiology

10.1016/j.jhlto.2023.100007

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Citations (2)

Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI)

Pulmonary Circulation (2019)

David G. Kiely David L. Levin Paul M. Hassoun D. Dunbar Ivy Pei‐Ni Jone

Pulmonary hypertension (PH) is highly heterogeneous and despite treatment advances it remains a life‐shortening condition. There have been significant advances in imaging technologies, but despite evidence of their potential clinical utility, practice remains variable, dependent in part on imaging availability and expertise. This statement summarizes current and emerging imaging modalities and their potential role in the diagnosis and assessment of suspected PH. It also includes a review of commonly encountered clinical and radiological scenarios, and imaging and modeling‐based biomarkers. An expert panel was formed including clinicians, radiologists, imaging scientists, and computational modelers. Section editors generated a series of summary statements based on a review of the literature and professional experience and, following consensus review, a diagnostic algorithm and 55 statements were agreed. The diagnostic algorithm and summary statements emphasize the key role and added value of imaging in the diagnosis and assessment of PH and highlight areas requiring further research.

Scope (computer science)

Statement (logic)

Modalities

Clinical Practice

10.1177/2045894019841990

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Citations (117)

The Radiographic Spectrum of Small Pulmonary Vascular Abnormalities in Idiopathic Pulmonary Fibrosis

Eileen M. Harder Pietro Nardelli Badar Patel Sirus Jesudasen Raúl San Jośe Estépar

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7375

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CT Characteristics of COPD Patients With Impaired Diffusion Capacity; Implications for COPD-pulmonary Hypertension Phenotyping

Shelsey W. Johnson Carrie P. Aaron Alejandro A. Díaz Bina Choi Pietro Nardelli

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7363

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Right and Left Pulmonary Artery Dilation in Pulmonary Hypertension

Shahryar Ansari Isaac de La Bruere Inderjit Singh Carolyn E. Come M. Faria Urbina

Dilation (metric space)

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3643

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Abstract 23080: Increased Pulmonary Peripheral (But Not Central) Blood Flow Correlates With Decreased Right Ventricular Volume in Acute Pulmonary Embolism Treated With Ultrasound-Facilitated, Catheter-Directed Fibrinolysis

Circulation (2017)

Gregory Piazza Farbod N. Rahaghi Samuel Z. Goldhaber Raúl San Jośe Estépar Jasleen Minhas

Introduction: Ultrasound-facilitated, catheter-directed fibrinolysis improves right ventricular (RV) function in patients with acute pulmonary embolism (PE). Resolution of central pulmonary arterial thrombotic obstruction has been hypothesized as the principal mechanism for RV recovery. Hypothesis: We postulated that improved peripheral blood flow rather than central blood flow correlates with reversal of RV enlargement due to PE. Methods: Using a 3-dimensional quantitative reconstruction technique that allows resolution of the distal pulmonary arteries, we analyzed the computed tomographic (CT) pulmonary angiograms of 60 submassive and massive PE patients treated with ultrasound-facilitated, catheter-directed, low-dose fibrinolysis. We correlated the change in blood volume of the pulmonary arteries (<10 mm 2 vs. >40 mm 2 cross sectional area) from baseline to 48 ± 6 hours with change in CT-measured RV volume. Results: Forty-five patients demonstrated reduction in RV volume (mean change was -31 ml). Increase in total lung blood volume/lung volume correlated with decreased RV volume/lung volume (R 2 = 0.26). RV volume-to-left ventricular volume ratio decreased by 26% ( Figure, Panel A ). Decreased RV volume correlated with increased blood volume through <10 mm 2 pulmonary arteries (R 2 = 0.28) but not larger pulmonary arteries (> 40 mm 2 ) (R 2 = 0.00003) ( Figure, Panel B1 and B2 ). Conclusion: Total lung blood volume increases following ultrasound-facilitated, catheter-directed fibrinolysis. Increased blood volume through the peripheral, but not central, pulmonary artery vasculature correlates with reduction in RV volume after ultrasound-facilitated catheter-directed fibrinolysis.

10.1161/circ.136.suppl_1.23080

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Citations (1)

Blood Glucose Dynamics

Diabetes Technology & Therapeutics (2008)

Farbod N. Rahaghi David Gough

Measurement of blood glucose concentration is central to the diagnosis and treatment of diabetes. Although there are large numbers of historic glucose measurements in individuals with diabetes, until recently there have been very few data sets that were recorded continuously or sampled frequently enough to reveal intrinsic blood glucose dynamics, or the change in blood glucose with time. There have even fewer such recordings from individuals not having diabetes to serve as a therapeutic target. As a result, blood glucose dynamics have generally not been used in the diagnosis or treatment of the disease. Although present blood glucose monitoring is based largely on discrete measurements, future monitoring will likely focus on analysis of blood glucose excursions. New measurements are now being obtained, and there is a need for new methods of analysis to extract the maximal information from the data. Several approaches are demonstrated here for characterization of blood glucose dynamics, and a patient profiling system is proposed. An example of new insights is the observation that there are four time scales of blood glucose variations in individuals without diabetes, and these time scales are modified or lost in diabetes.

Blood glucose monitoring

Blood Glucose Self-Monitoring

10.1089/dia.2007.0256

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Citations (37)