Lisa Matthews

Columbia University Irving Medical Center

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i-10 index

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Co-Authors

Peter D’Eustachio

New York University

Guanming Wu

Oregon Health & Science University

Lincoln Stein

Ontario Institute for Cancer Research

Marc Gillespie

St. John's University

Bijay Jassal

Ontario Institute for Cancer Research

Henning Hermjakob

European Bioinformatics Institute

Robin Haw

Ontario Institute for Cancer Research

Karen Rothfels

Ontario Institute for Cancer Research

Cristoffer Sevilla

European Bioinformatics Institute

Veronica Shamovsky

New York University

Cooperative Institutions

European Bioinformatics Institute

165

SIB Swiss Institute of Bioinformatics

154

Stanford University

140

University College London

132

University of Southern California

112

University of Padua

109

Phoenix Bioinformatics

109

University at Buffalo, State University of New York

104

Wellcome Trust

University of Cambridge

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The effect of immunocastration 7 weeks before slaughter on the behaviour, growth and meat quality of post-pubertal bulls

Animal Science (1999)

J. Jago Lisa Matthews T. E. Trigg P.M. Dobbie J. J. Bass

Abstract Active immunization against gonadotropin-releasing hormone (GnRH), commonly known as immunocastration, has been proposed as an alternative to traditional methods of castrating bulls. This study evaluated the effects of immunocastration on growth, behaviour and meat quality of post-pubertal bulls. Bulls were either vaccinated against GnRH (no. = 30, I) or left intact (no. = 30, B). A third treatment consisted of steers (no. = 20, S) that had been castrated pre-pubertally. The animals were run in eight single treatment groups (no. = 10 per group), three of each of В and I and two groups of S. Anti-GnRH antibodies developed and plasma testosterone concentrations declined in I following immunization. Aggressive behaviour of I declined to be lower ( P < 0·5) than B and no different from S, 5 weeks after primary immunization. Seven weeks after immunocastration all animals were slaughtered. The hot carcass weight of I was between that of B and S but not significantly different from either. There were no effects of treatment on pH u or meat colour measurements. Taste panel assessment rated I higher than B, but lower than S for tenderness, juiciness and overall palatability. These results demonstrate that immunocastration of post-pubertal bulls 7 weeks before slaughter is a potential means of reducing problematic bull behaviour and improving meat quality although this is likely to be at the cost of reduced weight gain.

Palatability

Active immunization

10.1017/s1357729800050189

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Citations (8)

Adobe Photoshop Elements 2.0 Idea Kit

Lisa Matthews

From the Publisher: With the arrival of Photoshop Elements came a number of books aimed at helping the digital photo enthusiast get the most out of the Adobe's slimmer Photoshop cousin. Adobe Photoshop Elements Idea Kit adds a unique twist to the melange: It steps readers through the processes of creating special effects and fixing problems in digital images and then hones in on how to use those images to easily create a variety of professional-looking projects. Hobbyists who want to make the most out of their snapshots to create a postcard, flyer, or personal Web page, as well as business users who need to create slide presentations, a customized Web gallery, or custom CD and video covers will find that Adobe Photoshop Elements Idea Kit is their newest best friend. Working templates of each project are included on the CD-ROM, making it easy to produce polished finished projects. The book begins by stepping readers through the basics of image correction, including how to color images by hand and add borders, and then moves on to basic layout strategies for a number of projects: using photographs in newsletters, creating flyers, posters, postcards, and more. The latter part of the book focuses on more complex layout projects such as slide presentations, Web pages and banners, and more. For anyone who wants or needs to produce creative digital-image projects without reinventing the wheel.

Adobe photoshop

Adobe

Source

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Stimulus requirements of housed pigs assessed by behavioural demand functions

Applied Animal Behaviour Science (1987)

Lisa Matthews Jan Ladewig

Hypervelocity

Shields

Kevlar

Muzzle

Watercraft

10.1016/0168-1591(87)90164-x

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Citations (50)

Community Health workers United to Reduce Colorectal cancer and cardiovascular disease among people at Higher risk (CHURCH): study protocol for a randomized controlled trial.

Research Square (Research Square) (2024)

Olajide Williams Tina Ting Lisa Matthews Gladys Block Torin Block

Abstract Background: Colorectal cancer (CRC) is the second most lethal cancer in the United States (U.S.) with the highest incidence and mortality rates among African Americans (AAs) compared to other racial groups. Despite these disparities, AAs are the least likely to undergo CRC screening, have precancerous colorectal polys removed, and have CRC detected at stages early enough for curative excision. In addition, compelling evidence links inflammatory dietary patterns to increased CRC and cardiovascular disease risk. Studies show that AA churches can successfully engage in health promotion activities including those related to cancer control. The current study seeks to leverage church-placed Community Health Workers (CHWs) to increase CRC screening and reduce CRC risk. Design and Methods: We aim to (1) increase guideline concordant CRC screening uptake using church-placed CHWs trained in screening with a validated instrument, Brief Intervention using Motivational Interviewing, and Referral to Treatment (SBIRT); and (2) reduce dietary risk factors (inflammatory dietary patterns) linked to CRC. The latter will be addressed by culturally adapting an existing, web-based lifestyle program called Alive!. Using a Hybrid Type 1 Implementation-Effectiveness cluster randomized design, we will randomize 22 AA churches into either the dual intervention arm (CHW-led SBIRT intervention plus Alive!) or a usual care arm comprised of CRC prevention educational pamphlets and a list of CRC screening sites. We will recruit 440 subjects and evaluate the effects of both arms on screening uptake (colonoscopy, fecal DNA) (primary outcome) and dietary inflammation score (secondary outcome) at 6-months follow up, and Life Simple7 (LS7) - a cardiovascular disease (CVD) risk score - at 6 months and 1-year (secondary outcome). Finally, guided by a racism-conscious adaptation of the Consolidated Framework for Implementation Research (CFIR), we will conduct a mixed- methods process evaluation with key stakeholders to understand multi-level influences on CRC screening and CVD risk behaviors. Discussion: Church-placed CHWs are trusted influential connectors between communities and health systems. Studies have shown that these CHWs can successfully implement health prevention protocols in churches, including those related to cancer control, making them potentially important community mediators of CRC screening uptake and CRC/CVD risk reduction. Trial registration: NCT05174286

Guideline

Cancer screening

Motivational Interviewing

Cancer Prevention

10.21203/rs.3.rs-3797889/v1

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Citations (0)

Cell-cell junction organization

Reactome - a curated knowledgebase of biological pathways (2009)

Lisa Matthews

10.3180/react_23419.1

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Citations (0)

NR1H2 and NR1H3-mediated signaling

Carolyn L. Cummins Joyce J. Repa Lisa Matthews

10.3180/r-hsa-9024446.2

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Citations (0)

Animal welfare and sustainability of production under extensive conditions: a non-EU perspective

Applied Animal Behaviour Science (1996)

Lisa Matthews

Animal Husbandry

Adaptability

10.1016/0168-1591(95)00666-4

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Citations (23)

Reactome enhanced pathway visualization

Bioinformatics (2017)

Konstantinos Sidiropoulos Guilherme Viteri Cristoffer Sevilla S Jupe Marissa Webber

Reactome is a free, open-source, open-data, curated and peer-reviewed knowledge base of biomolecular pathways. Pathways are arranged in a hierarchical structure that largely corresponds to the GO biological process hierarchy, allowing the user to navigate from high level concepts like immune system to detailed pathway diagrams showing biomolecular events like membrane transport or phosphorylation. Here, we present new developments in the Reactome visualization system that facilitate navigation through the pathway hierarchy and enable efficient reuse of Reactome visualizations for users' own research presentations and publications.For the higher levels of the hierarchy, Reactome now provides scalable, interactive textbook-style diagrams in SVG format, which are also freely downloadable and editable. Repeated diagram elements like 'mitochondrion' or 'receptor' are available as a library of graphic elements. Detailed lower-level diagrams are now downloadable in editable PPTX format as sets of interconnected objects.http://reactome.org.fabregat@ebi.ac.uk or hhe@ebi.ac.uk.

Scalable Vector Graphics

10.1093/bioinformatics/btx441

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Citations (162)

The Gene Ontology resource: enriching a GOld mine

Nucleic Acids Research (2020)

Seth Carbon Eric Douglass Benjamin M. Good Deepak Unni Nomi L. Harris

Abstract The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations.

Traceability

Gene Annotation

Schema (genetic algorithms)

Controlled vocabulary

10.1093/nar/gkaa1113

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Citations (3,063)

The reactome pathway knowledgebase

Nucleic Acids Research (2019)

Bijay Jassal Lisa Matthews Guilherme Viteri Chuqiao Gong Pascual Lorente

Abstract The Reactome Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism and other cellular processes as an ordered network of molecular transformations in a single consistent data model, an extended version of a classic metabolic map. Reactome functions both as an archive of biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. To extend our ability to annotate human disease processes, we have implemented a new drug class and have used it initially to annotate drugs relevant to cardiovascular disease. Our annotation model depends on external domain experts to identify new areas for annotation and to review new content. New web pages facilitate recruitment of community experts and allow those who have contributed to Reactome to identify their contributions and link them to their ORCID records. To improve visualization of our content, we have implemented a new tool to automatically lay out the components of individual reactions with multiple options for downloading the reaction diagrams and associated data, and a new display of our event hierarchy that will facilitate visual interpretation of pathway analysis results.

Upload

10.1093/nar/gkz1031

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Citations (2,035)