Leonardo Lacerenza

Misericordia Community Hospital

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Lin Zhang

Wuhan University

Ching-Yun Chang

Eli Lilly (United States)

Mario Corbellino

ASST Fatebenefratelli Sacco

Montanea Daniels

Eli Lilly (United States)

Justin Stebbing

Anglia Ruskin University

Venkatesh Krishnan

Eli Lilly (United States)

Jonathan T. Sims

South Australia Pathology

Stephanie Beasley

Eli Lilly (United States)

Fabio Lena

Ospedale Misericordia - Grosseto

Giacomo Casalini

ASST Fatebenefratelli Sacco

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Eli Lilly (United States)

University of Milan

Indiana University School of Medicine

Indiana University

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ASST Fatebenefratelli Sacco

Luigi Sacco Hospital

Imperial College London

Ospedale Misericordia - Grosseto

Misericordia Community Hospital

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Longitudinal Assessment of Systemic Steroid Therapy on Hyperinflammatory Endothelial Biomarker Profiles and Serology Responses of COVID-19 Patients

Research Square (Research Square) (2022)

Jonathan T. Sims Ching-Yun Chang Josh Poorbaugh Montanea Daniels Stephanie Beasley

Abstract This first of its kind study provides objective context to the potential mechanism of action of corticosteroid use in COVID-19 patients from 3 separate European medical centers by connecting inflammatory biomarkers to IgG levels for the SARS-CoV-2 spike protein antigens and neutralization of ACE2 binding within infected individuals. CXCL9 is described herein as an important COVID-19 biomarker connecting disease severity with inflammatory biomarker and serology response profiles in corticosteroid-treated patients.

10.21203/rs.3.rs-1217324/v1

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