ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of the crystal and molecular structures of cyclopentadienylbromodicarbonylruthenium(II) and (ethyltetramethylcyclopentadienyl)bromodicarbonylruthenium(II)Harry Adams, Neil A. Bailey, and Colin WhiteCite this: Inorg. Chem. 1983, 22, 8, 1155–1158Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://doi.org/10.1021/ic00150a002RIGHTS & PERMISSIONSArticle Views43Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (527 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The synthesis of the acyclic Schiff bases H4L7 and H2L8, derived from 1-(pyrrol-2-yl)butane-1,3-dione and 1,3-bis(2-aminophenoxy)propane, and from pyrrole-2-carbaldehyde and 3,6-dioxaoctane-1,8-diamine, respectively are reported, together with their respective copper(II) complexes. Crystals of [Cu(H2L7)] are monoclinic; R= 0.0549 for 1 901 observed reflections. The copper is co-ordinated in the inner (N2O2) compartment with a trans mode of attachment by the ligand; the approximately square-planar co-ordination geometry shows a significant tetrahedral distortion. The pyrrole and ether functions are not bonded to the copper. In the structure of [Cu(HL8)(O2CMe)](R= 0.0363, 4 800 reflections), the co-ordination geometries of the copper atoms in the two independent molecules are tetragonally-distorted octahedral, the two long axial bonds being to one acetate oxygen and to one of the ether oxygen atoms; one pyrrole residue is not co-ordinated to copper.
Functionalisation of a mononuclear barium Complex of a 24-membered bibracchial tetraimine Schiff-base Macrocycle (L1) derived from the barium-templated cyclocondensation of 2,6-diacetylpyridine and tris(2-aminoethyl)amine was attempted using salicylaldehyde. The reaction leads to the isolation of the tripodal ligand tris[2-(salicylideneamino)ethyl]amine (L2) and the complex BaL22(ClO4)2. The crystal structures of the parent macrocyclic complex, [BaL1][ClO4]2[monoclinic, space group P21/c(no. 14), a= 11.755(7), b= 21.733(17), c= 15.621(15)Å, β= 90.50(7)°, Z= 4], and BaL22(ClO4)2[monoclinic, space group P21/c(C2h5, no. 14), a= 12.299(15), b= 9.530(15), c= 25.798(32)Å, β= 108.679(9)°, Z= 2] have been determined.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Chemistry of Chiral Tetraphenylcyclopentadienes: X-ray Structures of Rh(.eta.5-C5Ph4R*)(.eta.4-C8H12) (R* = Menthyl, Neomenthyl)Jim A. Ramsden, David J. Milner, Harry Adams, Neil A. Bailey, Arnold J. Smith, and Colin WhiteCite this: Organometallics 1995, 14, 5, 2575–2584Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/om00005a065https://doi.org/10.1021/om00005a065research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative Addition of Alkyl Halides to Rhodium(I) and Iridium(I) Dicarbonyl Diiodides: Key Reactions in the Catalytic Carbonylation of AlcoholsPaul R. Ellis, Jean M. Pearson, Anthony Haynes, Harry Adams, Neil A. Bailey, and Peter M. MaitlisCite this: Organometallics 1994, 13, 8, 3215–3226Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/om00020a039https://doi.org/10.1021/om00020a039research-articleACS PublicationsRequest reuse permissionsArticle Views1122Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
<div>AbstractPurpose:<p>Clinical trials of venetoclax reported negligible rates of clinical tumor lysis syndrome (TLS) in patients with chronic lymphocytic leukemia (CLL) when using an extended dose escalation schedule. We aimed to understand TLS prophylaxis, rates of select adverse events (AE), and impact of dosing modifications in routine clinical practice.</p>Experimental Design:<p>This retrospective cohort study included 297 CLL venetoclax-treated patients outside of clinical trials in academic and community centers. Demographics, baseline disease characteristics, venetoclax dosing, TLS risk and prophylaxis, and AEs were collected.</p>Results:<p>The group was 69% male, 96% had relapsed/refractory CLL, 45% had deletion chromosome 17p, 84% had unmutated <i>IGHV</i>, 80% received venetoclax monotherapy, and median age was 67. TLS risk was categorized as low (40%), intermediate (32%), or high (28%), and 62% had imaging prior to venetoclax initiation. Clinical TLS occurred in 2.7% of patients and laboratory TLS occurred in 5.7%. Pre-venetoclax TLS risk group and creatinine clearance independently predict TLS development in multivariable analysis. Grade 3/4 AEs included neutropenia (39.6%), thrombocytopenia (29.2%), infection (25%), neutropenic fever (7.9%), and diarrhea (6.9%). Twenty-two patients (7.4%) discontinued venetoclax due to an AE. Progression-free survival was similar regardless of number of dose interruptions, length of dose interruption, and stable venetoclax dose.</p>Conclusions:<p>These data provide insights into current use of venetoclax in clinical practice, including TLS rates observed in clinical practice. We identified opportunities for improved adherence to TLS risk stratification and prophylaxis, which may improve safety.</p></div>
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