Abstract Chemotherapy turns tumor cells into “tumor vaccines” by immunogenic cell death (ICD). However, it remains a challenge to exploit chemotherapy‐induced “tumor vaccines” for solid cancer immunotherapy due to the inefficient effector T cells activation and tumor microenvironment immunosuppression. Here, a matrix metalloprotease 2 responsive liposome (PEG‐FA‐Lip) composed of cleavable PEG chains covering the folate (FA)‐modified liposome is developed to deliver ICD inducer doxorubicin. In breast cancer‐bearing mice, PEG‐FA‐Lip targets both 4T1 breast cancer cells and M2‐tumor associated macrophages (M2‐TAMs) via FA‐receptor mediated endocytosis, resulting in abundant “tumor vaccines” and efficient elimination of M2‐TAMs. The combination of local cytosine‐phosphate‐guanine (CpG) therapy facilitates PEG‐FA‐Lip induced “tumor vaccines” to effectively arouse systematic effector T cells immune response through promoting dendritic cell maturation and immunostimulatory cytokines secretion. The simultaneous elimination of M2‐TAMs ensures the activated effector T cells exert antitumor immunity within tumor via decreasing immunosuppressive cytokines secretion and tumor infiltration of Treg cells. After receiving the combined treatment, 30.1% of breast cancer‐bearing mice (initial tumor volume > 100 mm 3 ) achieves the goal of tumor eradication. Remarkably, this combination therapy greatly inhibits lung metastasis and controls the growth of already metastasized breast cancers (initial tumor volume > 100 mm 3 ).

Adjuvant Chemotherapy

10.1002/advs.201801868

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Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: Preparation and characterization

International Journal of Pharmaceutics (2007)

Jianjun Liu Tao Gong Chi Chiu Wang Zhenyang Zhong Z ZHANG

Solid lipid nanoparticle

Sodium Cholate

Zeta potential

10.1016/j.ijpharm.2007.03.009

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Citations (266)

An in situ forming gel co-loaded with pirarubicin and celecoxib inhibits postoperative recurrence and metastasis of breast cancer

International Journal of Pharmaceutics (2024)

Mengying Wu Zhang We Xueru Zhou Zijun Wang Sha Li

Celecoxib

Pirarubicin

10.1016/j.ijpharm.2024.123897

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Citations (1)

Saliva is a non‐negligible factor in the spread of COVID‐19

Molecular Oral Microbiology (2020)

Yuqing Li Biao Ren Xian Peng Tao Hu Jiyao Li

SARS-CoV-2, a novel emerging coronavirus, has caused severe disease (COVID-19), and rapidly spread worldwide since the beginning of 2020. SARS-CoV-2 mainly spreads by coughing, sneezing, droplet inhalation, and contact. SARS-CoV-2 has been detected in saliva samples, making saliva a potential transmission route for COVID-19. The participants in dental practice confront a particular risk of SARS-CoV-2 infection due to close contact with the patients and potential exposure to saliva-contaminated droplets and aerosols generated during dental procedures. In addition, saliva-contaminated surfaces could lead to potential cross-infection. Hence, the control of saliva-related transmission in the dental clinic is critical, particularly in the epidemic period of COVID-19. Based on our experience of the COVID-19 epidemic, some protective measures that can help reduce the risk of saliva-related transmission are suggested, in order to avoid the potential spread of SARS-CoV-2 among patients, visitors, and dental practitioners.

2019-20 coronavirus outbreak

10.1111/omi.12289

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Citations (201)

Dexamethasone palmitate encapsulated in palmitic acid modified human serum albumin nanoparticles for the treatment of rheumatoid arthritis.

Journal of Pharmaceutical Sciences (2024)

Yu Zhang Xueru Zhou Zijun Wang Mengying Wu Wei Zhang

Human albumin

Human serum albumin

Serum Albumin

10.1016/j.xphs.2024.07.013

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Self‐Delivered Transformable Nanosystem Capable of Enhancing Photodynamic Effectiveness and Multi‐Target Ameliorating Immunosuppression for Treatment of Breast Cancer and Lung Metastasis

Advanced Functional Materials (2024)

Ruyi Lin Jia Yan Bokai Gong Fan Tong Yujun Song

Abstract Homogeneous distribution and adequate accumulation of photosensitizer in tumor are essential for effective photodynamic therapy (PDT). However, the intricate tumor microenvironment (TME) often poses great challenges to the deep penetration and retention of therapeutic agents in tumor. Moreover, the important effect of PDT to induce specific antitumor immune response is impeded by multiple immunosuppressive mechanisms within TME. Confronting these issues, here a rationally designed nanosystem (SUN‐NPA) with acid‐responsive sphere‐to‐fiber transformation ability by leveraging the characters of drug molecules is proposed to achieve self‐delivery of photosensitizer Chlorin e6 (Ce6) and two small‐molecule immunomodulators, metformin (MET) and sunitinib (SUN). The spatiotemporal controlled transformation enables homogeneous distribution and high accumulation of drugs to achieve enduring PDT and complete tumor elimination. Meanwhile, the co‐delivered MET and SUN alleviate tumor immunosuppression from multiple aspects, effectively synergizing with PDT to ignite potent host immune response and long‐lasting immunological memory against tumor cells. The artful integration of enhanced PDT and activated antitumor immunity realized by SUN‐NPA leads to the significant inhibition of tumor growth and metastasis, exhibiting great potential for oncotherapy.

Immunosuppression

10.1002/adfm.202405051

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Inhibition of Streptococcus mutans growth and biofilm formation through protein acetylation

Molecular Oral Microbiology (2024)

Yongwang Lin Qizhao Ma Jiangchuan Yan Tao Gong Jun Huang

Numerous cellular processes are regulated in response to the metabolic state of the cell, and one such regulatory mechanism involves lysine acetylation. Lysine acetylation has been proven to play an important role in the virulence of Streptococcus mutans, a major cariogenic bacterial species. S. mutans' glucosyltransferases (Gtfs) are responsible for synthesizing extracellular polysaccharides (EPS) and contributing to biofilm formation. One of the most common nonsteroidal anti-inflammatory drugs is acetylsalicylic acid (ASA), which can acetylate proteins through a nonenzymatic transacetylation reaction. Herein, we investigated the inhibitory effects of ASA on S. mutans. ASA treatment was observed to impede the growth of S. mutans, leading to a reduction in the production of water-insoluble EPS and the formation of biofilm. Moreover, ASA decreased the enzyme activity of Gtfs while increasing the protein acetylation level. The in vivo anticaries efficacy of ASA has further been proved using the rat caries model. In conclusion, ASA as an acetylation agent attenuated the cariogenic virulence of S. mutans, suggesting the potential value of protein acetylation on antimicrobial and anti-biofilm applications to S. mutans.

10.1111/omi.12452

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Design and quality evaluation of self-emulsifying drug delivery systems for Combretastatin A4

Huaxi yaoxue zazhi (2010)

Tao Gong

OBJECTIVE To prepare self-emulsifying drug delivery systems ( SEDDS) of combretastatin A4 and evaluate its quality.METHODS The best formulation was optimized according to appearance and particle size of emulsions with ternary phase diagrams and the solubility and dissolution characteristics of SEDDS in three different medias were investigated.RESULTS The best formulation was CA4-Lauroglycol FCC-T20C-Transcutol P with weight ratio of 3∶50∶35∶15.The solubility of CA4 SEDDS was 66 mg·mL -1,and the drug totally released in 10 minutes in three media,suggesting that the effects of dissolution in three medias was close.CONCLUSION The self-emulsifying formulation can obviously improve the solubility of CA4 and the dissolution characteristics of CA4 SEDDS was not affected by different dissolution media.

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