<p>Representative images of pHH3 immunostaining (200x magnification), comparing untreated vehicle-treated with imatinib, avapritinib 10 mg/kg or 30 mg/kg treated tumors in three models.</p>
<p>Grading scheme for pMAPK immunostaining. Staining was graded based on the intensity of the staining and the percent of tumor area showing pMAPK positivity.</p>
<p>Supplementary Table S1. The outlier mRNA expression profiles of the gene tissue index (GTI) outlier analysis. The list of 2415 outlier genes in GIST is ranked by the gene tissue index.</p>
<p>Genomic profile, describing copy number gains and losses, obtained using low coverage whole genome sequencing of subsequent passages of STS PDX models, revealing a stable copy number profile throughout passaging. Copy number profile of (A) the MPNST model UZLX-STS39 and (B) the mesenchymal chondrosarcoma model UZLX-STS41.</p>
