Iva Gueorguieva

Université de Lille

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Chantal Stuckens

Centre Hospitalier Universitaire de Lille

Jacques Weill

Hôpital Jeanne de Flandre

Agnès Linglart

Université Paris-Saclay

Anya Rothenbühler

Swiss Federal Institute of Sport Magglingen SFISM

Pierre Bougnères

Inserm

François Pattou

Centre Hospitalier Universitaire de Lille

ÉL

Élodie Lespagnol

Unité de Recherche Pluridisciplinaire Sport, Santé, Société

Elsa Heyman

Unité de Recherche Pluridisciplinaire Sport, Santé, Société

Sémah Tagougui

Université de Lille

Brigitte Mignot

Centre Hospitalier Universitaire de Besançon

Cooperative Institutions

Inserm

202

Assistance Publique – Hôpitaux de Paris

Université de Lille

Centre Hospitalier Universitaire de Lille

Sorbonne Université

Centre National de la Recherche Scientifique

Université Paris Cité

Sorbonne Paris Cité

Fondation pour l’innovation en Cadiométabolisme et Nutrition

Hôpital Jeanne de Flandre

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Mécanisme des conséquences vasculaires pulmonaires immédiates d’un stress douloureux in-utero

Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction (2005)

B. De Jenlis Sicot V. Debarge Sylvie Jaillard Iva Gueorguieva Nathalie Rouaix

10.1016/s0368-2315(05)82872-8

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Interleukin-1 Receptor Antagonist Penetrates Human Brain at Experimentally Therapeutic Concentrations

Journal of Cerebral Blood Flow & Metabolism (2007)

Simon Clark Catherine McMahon Iva Gueorguieva Malcolm Rowland Sylvia Scarth

The proinflammatory cytokine interleukin (IL)-1 mediates several forms of experimentally induced acute brain injury and has been implicated in chronic neurodegenerative disorders. The IL-1 receptor antagonist, IL-1RA, protects rodents against ischaemic brain injury, but its molecular mass (17 kDa) potentially limits the brain penetration of peripherally administered IL-1RA. We therefore sought to identify whether therapeutically effective concentrations of IL-1RA in the rat were also achieved in brain of patients with subarachnoid haemorrhage (SAH), using a peripheral administration regime that had proved to be safe and reduce peripheral inflammation in patients after stroke. An intravenous bolus of IL-1RA, followed by infusion, was administered to rats after induction of focal cerebral ischaemia. The effects of IL-1RA on brain ischaemia and the concentrations achieved in cerebrospinal fluid (CSF), were determined. Interleukin-1 receptor antagonist was similarly administered to patients with SAH, and CSF was sampled via external ventricular drains. In rats, IL-1RA significantly reduced brain injury induced by focal cerebral ischaemia. The plasma IL-1RA concentrations reached 12+/-2 microg/mL by 30 mins, and CSF concentrations were maintained between 91 and 232 ng/mL between 1 and 24 h of infusion. In patients with SAH, IL-1RA reached a steady-state plasma concentration of 22+/-4 microg/mL by 15 mins, and CSF concentrations were maintained at 78 to 558 ng/mL between 1 and 24 h. Intravenous delivery of IL-1RA leads to CSF concentrations in patients comparable to those that are neuroprotective in rats, and might therefore be of therapeutic benefit.

10.1038/sj.jcbfm.9600537

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Citations (121)

Laparoscopic adjustable gastric banding (LAGB) in adolescents at Lille University Hospital

Appetite (2015)

Madeleine Gottrand Iva Gueorguieva E. Aubry Marie Pigeyre Robert Caïazzo

Gastric banding

10.1016/j.appet.2014.12.059

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X-linked hypophosphatemia and burosumab: Practical clinical points from the French experience

Joint Bone Spine (2021)

Justine Bacchetta Anya Rothenbühler Iva Gueorguieva Peter Kamenický Jean‐Pierre Salles

Hypophosphatemia

PHEX

Bone pain

Hypophosphatemic Rickets

Nephrocalcinosis

10.1016/j.jbspin.2021.105208

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Citations (19)

Les freins à l’activité physique chez les enfants et adultes avec un diabète de type 1 : Quels liens réels avec les excursions glycémiques lors de l’activité physique ?

Cassandra Parent Élodie Lespagnol Serge Berthoin Sémah Tagougui Joris Heyman

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Adult height improved over decades in patients with X-linked hypophosphatemia: a cohort study

European Journal of Endocrinology (2023)

Emese Boros Diana‐Alexandra Ertl Jugurtha Berkenou Christelle Audrain Anne Lise Lecoq

The aim of this study is to analyze height after cessation of growth (final height [FH]) and its evolution over the last decades in X-linked hypophosphatemia (XLH) patients in France, as the data on natural history of FH in XLH are lacking.We performed a retrospective observational study in a large cohort of French XLH patients with available data on FH measurements.We divided patients into 3 groups according to their birth year: group 1 born between 1950 and 1974, group 2 born between 1975 and 2000, and group 3 born between 2001 and 2006, respectively, and compared their FHs.A total of 398 patients were included. Mean FHs were the following: for group 1, -2.31 ± 1.11 standard deviation score (SDS) (n = 127), 156.3 ± 9.7 cm in men and 148.6 ± 6.5 cm in women; for group 2, -1.63 ± 1.13 SDS (n = 193), 161.6 ± 8.5 cm in men and 153.1 ± 7.2 cm in women; and for group 3, -1.34 ± 0.87 SDS (n = 78), 165.1 ± 5.5 cm in men and 154.7 ± 6 cm in women. We report a significant increase in mean FH SDS over 3 generations of patients, for both men and women (P < .001). Final height SDS in male (-2.08 ± 1.18) was lower than in female (-1.70 ± 1.12) (P = .002).The FH of XLH patients in France increased significantly over the last decades. Even though men's FHs improved more than women's, men with XLH remain shorter reflecting a more severe disease phenotype. While the results are promising, most patients with XLH remain short leaving room for improvement.

Hypophosphatemia

10.1093/ejendo/lvad144

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Citations (1)

Molecular analysis of WNT4 gene in four adolescent girls with mullerian duct abnormality and hyperandrogenism (atypical Mayer-Rokitansky-K €

Pascal Philibert Anna Biason‐Lauber Iva Gueorguieva Chantal Stuckens Catherine Pienkowski

syndrome) In a collaborative study, we investigated four 46,XX adolescent girls with Mayer-Rokitansky-K€ syndrome and hyperandrogenism. Molecular analysis of the WNT4 gene permitted us to identify a new mutation (p.A233T). Functional studies revealed partial repression of steroidogenic enzymes (normal repression of HSD3B2) contrasting with the abnormal reexpression of CYP17A1 enzyme in the OVCAR3 cell line. This fourth new WNT4 mutation confirms that this signaling molecule is involved in mullerian development and androgen biosynthesis repression in the ovary. Interestingly, this mutant partially lacks the capability to repress ovarian steroidogenic enzymes, with abnormal expression of 17a- hydroxylase. (Fertil Steril� 2011;95:2683‐6. � 2011 by American Society for Reproductive Medicine.)

WNT4

Hyperandrogenism

CYP17A1

Anti-Müllerian hormone

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Are Children with Congenital Primary Hypothyroidism Overtreated

54th Annual ESPE (2015)

Claire Sechter Francis Vasseur Maryse Cartigny-Maciejewski Iva Gueorguieva Chantal Stuckens

Congenital hypothyroidism

Primary (astronomy)