Mikkel Christensen

Frederiksberg Hospital

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G. Maslen

European Bioinformatics Institute

James E. Allen

University of Manchester

Daniel Lawson

University of Notre Dame

Ernesto Lowy

European Bioinformatics Institute

Robert M. Waterhouse

SIB Swiss Institute of Bioinformatics

Richard K. Wilson

Nationwide Children's Hospital

Wesley C. Warren

University of Missouri

Patrick Minx

Donald Danforth Plant Science Center

Rosaline W. Macharia

University of Nairobi

Grazia Savini

University of Pavia

Cooperative Institutions

European Bioinformatics Institute

127

Wellcome Trust

112

Wellcome Sanger Institute

Universidade Federal do Rio de Janeiro

Lawrence Livermore National Laboratory

University of Cambridge

Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular

Cornell University

Cold Spring Harbor Laboratory

University of Pennsylvania

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Database of queryable gene expression patterns for Xenopus

Developmental Dynamics (2009)

Michael J. Gilchrist Mikkel Christensen Odile Bronchain Frédéric Brunet Albert Chesneau

Abstract The precise localization of gene expression within the developing embryo, and how it changes over time, is one of the most important sources of information for elucidating gene function. As a searchable resource, this information has up until now been largely inaccessible to the Xenopus community. Here, we present a new database of Xenopus gene expression patterns, queryable by specific location or region in the embryo. Pattern matching can be driven either from an existing in situ image, or from a user‐defined pattern based on development stage schematic diagrams. The data are derived from the work of a group of 21 Xenopus researchers over a period of 4 days. We used a novel, rapid manual annotation tool, XenMARK, which exploits the ability of the human brain to make the necessary distortions in transferring data from the in situ images to the standard schematic geometry. Developmental Dynamics 238:1379–1388, 2009. © 2009 Wiley‐Liss, Inc.

Schematic

Expression (computer science)

10.1002/dvdy.21940

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Citations (18)

Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts

Atherosclerosis (2007)

Shah Ebrahim Debbie A. Lawlor Yoav Ben‐Shlomo Nicholas J. Timpson Roger Harbord

10.1016/j.atherosclerosis.2007.02.002

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Citations (34)

Author response for "The impact of type 2 diabetes and glycaemic control on mortality and clinical outcomes in hospitalized patients with <scp>COVID</scp>‐19 in the capital region of Denmark"

Vivian Kliim‐Hansen Karl Sebastian Johansson Lærke S. Gasbjerg Espen Jimenez‐Solem Tonny Studsgaard Petersen

Capital (architecture)

10.1111/dom.15302/v2/response1

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Biased exon/intron distribution of cryptic and de novo 3' splice sites

Nucleic Acids Research (2005)

Jana Královičová Mikkel Christensen Igor Vořechovský

We compiled sequences of previously published aberrant 3′ splice sites (3′ss) that were generated by mutations in human disease genes. Cryptic 3′ss, defined here as those resulting from a mutation of the 3′YAG consensus, were more frequent in exons than in introns. They clustered in ∼20 nt region adjacent to authentic 3′ss, suggesting that their under-representation in introns is due to a depletion of AG dinucleotides in the polypyrimidine tract (PPT). In contrast, most aberrant 3′ss that were induced by mutations outside the 3′YAG consensus (designated ' de novo ') were in introns. The activation of intronic de novo 3′ss was largely due to AG-creating mutations in the PPT. In contrast, exonic de novo 3′ss were more often induced by mutations improving the PPT, branchpoint sequence (BPS) or distant auxiliary signals, rather than by direct AG creation. The Shapiro–Senapathy matrix scores had a good prognostic value for cryptic, but not de novo 3′ss. Finally, AG-creating mutations in the PPT that produced aberrant 3′ss upstream of the predicted BPS in vivo shared a similar 'BPS-new AG' distance. Reduction of this distance and/or the strength of the new AG PPT in splicing reporter pre-mRNAs improved utilization of authentic 3′ss, suggesting that AG-creating mutations that are located closer to the BPS and are preceded by weaker PPT may result in less severe splicing defects.

Polypyrimidine tract

Splice site mutation

splice

10.1093/nar/gki811

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Citations (61)

Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

Science (2014)

Daniel E. Neafsey Robert M. Waterhouse Mohammad Reza Abai Sergey Aganezov Max A. Alekseyev

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.

Entomology

10.1126/science.1258522

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Citations (551)

Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women’s Heart and Health Study

Diabetologia (2006)

Mikkel Christensen Debbie A. Lawlor Tom R. Gaunt Martin W. Howell George Davey Smith

Minor allele frequency

Linkage Disequilibrium

Genetic Association

10.1007/s00125-006-0145-3

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Citations (13)

A 30-Mb Metric Fluorescencein SituHybridization Map of Human Chromosome 19q

Genomics (1995)

Laurie Gordon Anne Bergmann Mikkel Christensen L. Danganan D.A. Lee

Cosmid

Physical mapping

10.1006/geno.1995.9886

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Citations (27)

Status Of The National Ignition Facility (NIF) Integrated Computer Control And Information Systems

G. Allen Bowers G. Brunton A Casey A. J. Churby Mikkel Christensen

Discusses the status of the control and information systems to support a wide variety of experiments being conducted on NIF including ignition experiments.

National Ignition Facility

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Citations (2)

Additional file 4: of Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes

Figshare (2019)

Geoffrey M. Attardo Adly M. M. Abd‐Alla Álvaro Acosta-Serrano James E. Allen Rosemary Bateta

Orthology group species composition data. (XLSX 3807 kb)

10.6084/m9.figshare.9760124

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Citations (0)

Experience applying light typerTM methodology to human SNPs relevant to growth and cardiovascular risk

Tom R. Gaunt Lesley J. Hinks Mikkel Christensen Matthew Kiessling Ian N.M. Day

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Citations (4)