Carlos Augusto Araújo Valadão

Universidade Estadual Paulista (Unesp)

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Paulo Aléscio Canola

Universidade Estadual Paulista (Unesp)

Renata Gebara Sampaio Dória

Universidade de São Paulo

André Escobar

Ross University School of Veterinary Medicine

Luciane Maria Laskoski

Universidade Federal do Paraná

Nilson Oleskovicz

Universidade do Estado de Santa Catarina

Júlio Carlos Canola

Universidade Estadual Paulista (Unesp)

ÉC

Érica Cristina Bueno do Prado Guirro

Universidade Federal do Paraná

João Henrique Perotta

Universidade Federal do Paraná

Juan Carlos Duque

Universidade Federal do Paraná

Juliana Regina Peiró

Universidade Estadual Paulista (Unesp)

Cooperative Institutions

Laboratoire Lorrain de Recherche en Informatique et ses Applications

447

Universidade Estadual Paulista (Unesp)

163

University of Liverpool

Liverpool Heart and Chest Hospital

Liverpool John Moores University

Universidade de São Paulo

Núcleo de Pesquisas Aplicadas (Brazil)

Aalborg University

Sapienza University of Rome

Universidade Federal do Paraná

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Expression of matrix metalloproteases-2 and -9 in horse hoof laminae after intestinal obstruction, with or without Hydrocortisone treatment

Ciência Rural (2012)

Luciane Maria Laskoski Carlos Augusto Araújo Valadão Rosemeri de Oliveira Vasconcelos Danilo Lopes Ferrucci Juliete A.F. Silva

Twenty horses were used in the experiment, for composed control group, (Cg) instrumented group, (Ig;without intestinal obstruction), treated group (Tg;submitted to intestinal obstruction and hydrocortisone treatment) and non-treated group (Ntg;submitted to intestinal obstruction without treatment). Immunohistochemistry and zymography techniques were used for researches on MMPs 2 and 9 in horse hoof laminae. There was an increase in the expression of MMP-2 in animals of Tg and Ntg. MMP-9 increased on animals from groups Ntg and Ig, however there was no rise of this MMP on the Tg when compared to the other groups in the immunohistochemistry analysis. Based on the results, it was observed that the intestinal injury caused by enterotomy and intestinal obstruction raise the quantities of MMPs in the hoof laminae.

Enterotomy

Hoof

Zymography

10.1590/s0103-84782013000100012

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Citations (4)

Horner-s Syndrome following common carotid artery translocation in a horse: case report

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2014)

Cássia Maria Molinaro Coelho M.C.S. Lopes Fabíola Niederauer Flôres Darcio Zangirolami Filho Paulo Aléscio Canola

Horner's syndrome (HS) is a sympathetic dysfunction caused by injuries to the sympathetic pathway. A clinical case of HS following common carotid artery transposition and catheterization in a horse is described. The animal presented head and neck sweating with focal skin temperature elevation, facial paralysis and ptosis. Most clinical signs were transient and persisted for two hours following percutaneous catheter removal. Recurrence of clinical signs was observed at subsequent catheterizations. Ptosis endured for 10 months as a consequence of the first catheter placement which demonstrates the importance of careful manipulation of the anatomical structures of the neck when performing any surgical manipulation in this area.

Horner syndrome

10.1590/1678-6771

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Citations (1)

Endotoxemia por lipopolissacarídeo de Escherichia coli, em eqüinos: efeitos de antiinflamatórios nas concentrações sérica e peritoneal do fator de necrose tumoral alfa (TNF-alfa)

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2007)

R.C. Campebell Juliana Regina Peiró P.C.S. Rosa Carlos Augusto Araújo Valadão Gervásio Henrique Bechara

Avaliou-se a inibição da produção do fator de necrose tumoral alfa (TNF-alfa) devido ao pré-tratamento com antiinflamatório esteroidal (dexametasona) e não esteroidal (diclofenaco sódico) em eqüinos com endotoxemia induzida experimentalmente. Foram utilizados 15 cavalos machos não castrados, distribuídos em três grupos de cinco animais: controle (C), diclofenaco sódico (DS) e dexametasona (DM). A endotoxemia subletal foi induzida pela infusão intravenosa (IV) de 0,1mg/kg/pv de lipopolissacarídeo (LPS) de Escherichia coli 055:B5, administrado em 250ml de solução estéril de cloreto de sódio a 0,9%, durante 15min. Os cavalos do grupo-controle foram tratados com solução de cloreto de sódio a 9% IV. Nos animais do grupo DS, administraram-se, por via oral, 2,2mg/kg de diclofenaco sódico e, nos do grupo DM, 1,1mg/kg de dexametasona IV, respectivamente, 60 e 30min antes da infusão da endotoxina. Mensurou-se, por meio de ensaio de toxicidade com células da linhagem L929, a concentração de TNF-alfa no soro e no líquido peritoneal às 0, 1¼, 3 e 6 horas após injeção do LPS. No grupo-controle, observou-se aumento significativo de TNF-alfa sérico, em relação ao valor basal e aos grupos DS e DM, 1,15 horas após a indução da endotoxemia. No líquido peritoneal, as concentrações observadas estavam abaixo daquelas da curva padrão de TNF-alfa, não havendo diferença entre os grupos (P>0,05).

10.1590/s0102-09352007000400003

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Citations (14)

Analysis of amitraz in cats by gas chromatography

Journal of Veterinary Pharmacology and Therapeutics (2010)

Cleidemar Moura Marafon Claudia Isabel Guastini Delfim Carlos Augusto Araújo Valadão R. MENOTTI Silvia Franco Andrade

Amitraz

10.1111/j.1365-2885.2009.01144.x

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Citations (9)

CANULAÇÃO CECAL EM EQUINOS

Ciência Animal Brasileira (2010)

Andrea Del Pilar Uribe Diaz Áureo Evangelista Santana Carlos Augusto Araújo Valadão Adriana Helena de Souza

Gastrointestinal diseases play an important role in the systemic alteration in horses. Several studies have been performed in order to better understand these processes. For these studies, to place a cannula inside the animal is a requirement. This study aimed to describe the surgical technique to place a cecal cannula in horses and the major postoperative changes. Nine adults and mixed breed horses were used in this study. The surgical procedure was performed in two steps. Primarily, through an incision in the right costal region, the dorsal segment of the cecum was sutured against the abdominal wall. In the second procedure, after the incision in the segment of the cecum, a canula was placed in the cecal lumen and sutured against the abdominal wall. This technique was viable when performed in two separated surgical procedures. The latex cannulas were well accepted by the horses, samples from the cecum could be collected throughout a period from 120 to 160 days, being considered appropriated for experimental procedures.KEYWORDS: Cecostomy, cecum, horses, intestinal cannulation.

Cecum

Lumen (anatomy)

Caecum

10.5216/cab.v11i2.1206

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Citations (7)

Efeitos comportamental, clínico e analgésico promovidos pela injeção epidural preventiva de morfina, xilazina ou clonidina, em equinos

Ciência Rural (2011)

Érica Cristina Bueno do Prado Guirro Guilherme Roberto Sobrinho Isabella Maria Marchesini Ferreira Carlos Augusto Araújo Valadão

Os agonistas dos receptores adrenérgicos 2 e os opioides tem ação analgésica e a aplicação preventiva pela via epidural pode minimizar os efeitos clínicos e comportamentais indesejáveis. Assim, avaliaram-se os efeitos comportamental, clínico e analgésico promovidos pela injeção epidural preventiva de morfina (0,1mg kg-1), xilazina (0,17mg kg-1) ou clonidina (3µg kg-1) durante 24 horas, em 18 equinos submetidos a um modelo incisional de dor inflamatória e avaliados pelos filamentos de von Frey. As alterações comportamentais, de frequência cardíaca, frequência respiratória, temperatura retal e altura de cabeça em relação ao solo foram mínimas e transitórias. A sensibilidade cutânea em pele incisada foi semelhante à sensibilidade da pele íntegra por 24, 8 e 12 horas após a administração epidural preventiva de morfina, xilazina ou clonidina, respectivamente, em equinos submetidos ao modelo incisional de dor inflamatória e avaliados com filamentos de von Frey. Além disso, não ocorreram alterações clínicas ou comportamentais importantes ao longo de 24 horas.

10.1590/s0103-84782011001000019

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Citations (3)

Alternative Intrabladder Manometry Technique for the Indirect Measurement of Intra-abdominal Pressure in Horses

Journal of Equine Veterinary Science (2012)

Paulo Aléscio Canola João Henrique Perotta Deborah Penteado Martins Dias Júlio Carlos Canola Philip J. Johnson

Although indirect methods for estimating intra-abdominal pressure (IAP) have been extensively studied in humans, mainly for identification of IAP increments in critical care unit patients (life-threatening condition), little work has been performed in veterinary medicine, especially in horses. The standard method of acquisition of intrabladder pressure (IBP) in human subjects (fluid-filled system with no balloon distention) has been previously evaluated in horses with an unfavorable outcome. Therefore, we reexamined the previously performed method of IBP investigation in horses by using an air-filled intrabladder manometry system in female horses. Intrabladder pressure was estimated by air-filled balloon manometry in seven healthy adult mares. The results were compared with two sets of directly acquired IAP values obtained by right paralumbar puncture using an 8-G needle in seven horses. Direct IAP values were obtained at times unrelated to IBP measurement acquisitions, and three of the seven horses used (for direct IAP measurement) were different animals from the mares used for assessment of IBP. Both sets of IAP measurements yielded subatmospheric values (IAP1 = −10.5 ± 2.2 mm Hg; IAP2 = −11.6 ± 2.0 mm Hg). Slightly subatmospheric IBP values were also recorded in some mares, but the mean (±SD) IBP was 1.4 ± 2.0 mm Hg. There was no correlation between IBP and IAP. These results suggest that this indirect (IBP) method for estimating IAP is not applicable for female horses.

Positive pressure

10.1016/j.jevs.2011.08.017

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Citations (4)

Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry

Journal of Thrombosis and Thrombolysis (2023)

Wern Yew Ding Ameenathul M. Fawzy Giulio Francesco Romiti Marco Proietti Daniele Pastori

Abstract The 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF registry were included. Major adverse cardiac events (MACEs) were defined as the composite outcome of stroke, myocardial infarction and cardiovascular death. Cox proportional hazards were used to examine the relationship between the 2MACE score and study outcomes. Predictive capability of the 2MACE score was investigated using receiver-operating characteristic curves. A total of 25,696 patients were included (mean age 71 years, female 44.9%). Over 3 years, 1583 MACEs were recorded. Patients who had MACE were older, with more cardiovascular risk factors and were less likely to be managed using a rhythm-control strategy. The median 2MACE score in the MACE and non-MACE groups were 2 (IQR 1–3) and 1 (IQR 0–2), respectively (p < 0.001). The 2MACE score was positively associated with an increase in the risk of MACE, with a score of ≥ 2 providing the best combination of sensitivity (69.6%) and specificity (51.6%), HR 2.47 (95% CI, 2.21–2.77). The 2MACE score had modest predictive performance for MACE in patients with AF (AUC 0.655 (95% CI, 0.641–0.669)). Our analysis in this prospective global registry demonstrates that the 2MACE score can adequately predict the risk of MACE (defined as myocardial infarction, CV death and stroke) in patients with AF. Clinical trial registration: http://www.clinicaltrials.gov . Unique identifiers: NCT01468701, NCT01671007 and NCT01937377

Mace

10.1007/s11239-023-02866-y

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Citations (5)

ESTUDO ELETROCARDIOGRÁFICO EM CÃES SUBMETIDOS À APLICAÇÃO INTRAVENOSA DE AMITRAZ.

Alberto Queiróz Farias Carlos Augusto Araújo Valadão Nilson Oleskovicz

Amitraz is a widely used alpha-two agonist insecticide and acaricide formamidine that is very effective to control ectoparasites. This drug can promote dose-dependent changes in cardiovascular parameters, such as bradycardia, first and second-degree atrioventricular block, decreased cardiac output, hypertension, and hypotension. Therefore, the aim of this research was to evaluate the possible electrocardiographic changes in dogs receiving an intravenous injection of amitraz. Eleven healthy mongrel mature dogs of either sex were used. They were given amitraz 1mg.kg-1 by intravenous route. Electrocardiography was recorded immediately before (baseline level) and then at 1, 5, 10, 20, 30, 40, 50, and 60 minutes after the drug administration. A paired t test was used to analyze data at a significance level of 5% (p<0.05). According to results, amitraz decreased the duration of P wave, and increased QT, PT, and RR intervals. The QRS complex remained unchanged, and a severe bradycardia was observed. It is possible to assume that amitraz produced typical alphatwo agonist cardiovascular effects, leading to bradycardia, although neither first nor second-degree atrioventricular block were observed.

Amitraz

Atrioventricular block

PR interval

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Citations (3)

Avaliação hemodinâmica e metabólica da cetamina e cetamina S(+) após a reposição volêmica com hidroxietilamido 130/0,4 e solução salina hipertônica 7,5%

Ciência Rural (2008)

Nilson Oleskovicz Juan Carlos Duque Erica Cristina Prado Guirro Carlos Augusto Araújo Valadão Denise Tabacchi Fantoni

O objetivo deste estudo foi avaliar os efeitos hemodinâmicos e metabólicos, após a administração de solução salina hipertônica (NaCL) 7,5% ou em associação ao hidroxietilamido (HES), em cães com hipovolemia induzida e tratados com cetamina. Após a indução da hipovolemia, administrou-se NaCl 7,5% (4,0ml kg-1) no grupo hipertônica levógira (GHL) e grupo hipertônica racêmica (GHR) ou HES 130/0,4 na mesma proporção de sangue retirado, associado a NaCl 7,5% (4ml kg-1) no grupo hipertônica colóide levógira (GHCL) e no grupo hipertônica colóide racêmica (GHCR). Após 30 minutos, administrou-se, por via IV, cetamina levógira (CL) (5mg kg-1) no GHL e GHCL ou cetamina racêmica (CR) (10mg kg-1) no GHR e GHCR. Empregou-se a análise de variância de uma única via com repetições múltiplas (ANOVA) e o teste de Student Newman Keuls (P<FONT FACE=Symbol>£</FONT>0,05). A frequência cardíaca e a pressão arterial sistólica foram menores após a hipovolemia e após a CR. As pressões arteriais média e diastólica foram menores após a hipovolemia e cetamina. A pressão venosa central foi maior após a administração do colóide. Os índices cardíaco e sistólico foram menores após a hipovolemia em todos os grupos e, após a fase de expansão no GHL e GHR. A pressão média da artéria pulmonar foi menor após a hipovolemia em todos os grupos. A pressão de oclusão da artéria pulmonar foi maior após o colóide. O índice do trabalho ventricular esquerdo foi menor após a hipovolemia no GHCL e GHCR. O índice da resistência periférica total foi maior após a hipovolemia e menor após a CL. Observou-se acidose metabólica após a hipovolemia e após a cetamina. Ocorreu acidose respiratória após a cetamina no GHL e GHR. Conclui-se que a administração de NaCl 7,5% associado ao HES 130/0,4 promove o restabelecimento imediato dos parâmetros hemodinâmicos e metabólicos no paciente hipovolêmico; a administração isolada de NaCl 7,5% não é capaz de restaurar a PAM no período imediato, mas melhora os demais parâmetros hemodinâmicos e metabólicos; a administração de CR ou CL produz efeitos hemodinâmicos e metabólicos similares no paciente hipovolêmico.

10.1590/s0103-84782008000400017

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Citations (2)