E Weidle

University of Tübingen

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A Wessing

Essen University Hospital

Klaus W. Ruprecht

Saarland University

Elmar P. Messmer

Augenklinik Heidelberg

H. Laqua

Universitäts-Augenklinik Bonn

Manfred Spitznas

University of Bonn

K-FR Sewing

University of Tübingen

Naumann Go

Friedrich-Alexander-Universität Erlangen-Nürnberg

Gottfried O.H. Naumann

Friedrich-Alexander-Universität Erlangen-Nürnberg

Cooperative Institutions

He Eye Hospital

Universitäts-Augenklinik Bonn

Friedrich-Alexander-Universität Erlangen-Nürnberg

Essen University Hospital

Augenklinik Heidelberg

Universitätsaugenklinik Magdeburg

University of California, Los Angeles

Klinik und Poliklinik für Augenheilkunde Universitätsklinikum Regensburg

University of Tübingen

Ophthalmology Associates (United States)

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[Cavernous hemangioma of the retina].

PubMed (1982)

Elmar P. Messmer H. Laqua A Wessing Manfred Spitznas E Weidle

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Citations (1)

Nine Cases of Cavernous Hemangioma of the Retina

American Journal of Ophthalmology (1983)

Elmar P. Messmer H. Laqua A Wessing Manfred Spitznas E Weidle

Angioma

Saccular aneurysm

Epiretinal Membrane

10.1016/s0002-9394(14)78309-6

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Citations (64)

The effect of submaximal doses of pentagastrin on gastric acid secretion, histamine and histidine decarboxylase in rats

Journal of Pharmacy and Pharmacology (1973)

E Weidle K-FR Sewing

Abstract In Lai-rats gastric mucosal histamine and histidine decarboxylase were estimated after stimulation of gastric acid secretion by intravenous infusions of submaximal doses of pentagastrin for 1 or 2 h. Pentagastrin produced a dose-dependent acid response with a maximum of 26 μ equiv H+ per 10 min at a dose of 2.56 μg kg−1 min−1. There was a linear relation between the log dose of pentagastrin and the activation of gastric histidine decarboxylase. The highest dose of pentagastrin yielded a histidine decarboxylase activity of 200% of the unstimulated level when infused for 1 h and of 290% when infused for 2 h. No reduction of gastric mucosal histamine could be detected whatever the dose of pentagastrin or the duration of infusion. It was concluded (1) that stimulation of gastric histidine decarboxylase is a physiological function of gastrin-like peptides, (2) that a reduction of gastric mucosal histamine by gastrin or pentagastrin is a pharmacological rather than a physiological effect, and (3) that no negative feedback relation exists beween gastric mucosal histamine and the activation of histidine decarboxylase.

Pentagastrin

Histidine decarboxylase

10.1111/j.2042-7158.1973.tb10630.x

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Citations (6)