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David Parry

Schering-Plough

26

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2576

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The identification of novel 5′-amino gemcitabine analogs as potent RRM1 inhibitors

2014 Bioorganic & Medicinal Chemistry
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A functional approach reveals a genetic and physical interaction between ribonucleotide reductase and CHK1 in mammalian cells.

2014 PLOS ONE
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Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor

2014 Bioorganic & Medicinal Chemistry Letters
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Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors.

2013 Bioorganic & Medicinal Chemistry Letters
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Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro

2012 Clinical Cancer Research
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Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA Damaging Agents and Antimetabolites

2012 Molecular Cancer Therapeutics
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Phase I and Pharmacologic Trial of Cytosine Arabinoside with the Selective Checkpoint 1 Inhibitor Sch 900776 in Refractory Acute Leukemias

2012 Clinical Cancer Research
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Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 2.

2011 Bioorganic & Medicinal Chemistry Letters
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Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified Via High Content Screening

2011 Molecular Cancer Therapeutics
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Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors.

2010 Bioorganic & Medicinal Chemistry Letters
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Citations (32)