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Hardik J. Patel

Memorial Sloan Kettering Cancer Center

34

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708

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Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system.

2021 Nature Communications
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Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone.

2020 Cell Reports
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Copper mediated coupling of 2-(piperazine)-pyrimidine iodides with aryl thiols using Cu(I)thiophene-2-carboxylate

2017 Tetrahedron Letters
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Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease

2016 Chemistry & Biology
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Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease

2016 Current Topics in Medicinal Chemistry
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Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.

2015 Journal of Molecular Biology
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Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94

2015 Journal of Medicinal Chemistry
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Abstract 2831: Development of selective GRP94 inhibitors for the treatment of cancer

2015 Cancer Research
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Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

2014 Journal of Medicinal Chemistry
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myeloproliferative neoplasms Improved targeting of JAK2 leads to increased therapeutic efficacy in

2014
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