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Lakshmi Balagopalan

National Institutes of Health

29

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1740

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Microclusters as T Cell Signaling Hubs: Structure, Kinetics, and Regulation

2021 Frontiers in Cell and Developmental Biology
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Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

2018 Nature Communications
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Absence of both Sos‐1 and Sos‐2 in peripheral CD4+ T cells leads to PI3K pathway activation and defects in migration

2015 European Journal of Immunology
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Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules

2015 Gene Therapy
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Enhanced Function of Redirected Human T Cells Expressing Linker for Activation of T Cells That Is Resistant to Ubiquitylation

2013 Human Gene Therapy
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Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

2013 Molecular and Cellular Biology
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The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from Its Guanine Nucleotide Exchange Activity in Vivo

2013 Science Signaling
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Enhanced T cell activation in lymphocytes from transgenic mice expressing LAT molecules resistant to ubiquitination

2012 Journal of Immunology
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Enhanced T cell signaling in cells bearing LAT molecules resistant to ubiquitylation

2011 The FASEB Journal
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Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

2011 Immunity
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Citations (246)