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Maxwell R. Tucker
Maxwell R. Tucker
D. E. Shaw Research
Signal transduction
Kinase
Cell membrane
Molecular switch
MAPK/ERK pathway
4
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14
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Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic BRAF signaling.
2021
Cancer Discovery
Christos Adamopoulos
Tamer A Ahmed
Maxwell R. Tucker
Peter Man-Un Ung
Min Xiao
Zoi Karoulia
Angelo Amabile
Xuewei Wu
Stuart A. Aaronson
Celina Ang
Vito W Rebecca
Brian D. Brown
Avner Schlessinger
Meenhard Herlyn
Qi Wang
David E. Shaw
Poulikos I. Poulikakos
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Citations (4)
A structural model of a Ras-Raf signalosome.
2021
Nature Structural & Molecular Biology
Venkatesh Mysore
Zhi Wei Zhou
Chiara Ambrogio
Lianbo Li
Jonas N. Kapp
Chunya Lu
Qi Wang
Maxwell R. Tucker
Jeffrey J. Okoro
Gabriela Nagy-Davidescu
Xiao Chen Bai
Andreas Plückthun
Pasi A. Jänne
Kenneth D. Westover
Yibing Shan
David E. Shaw
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Citations (1)
Abstract 78: A strategy for effective targeting of oncogenic BRAF signaling with increased therapeutic index using conformation-selective RAF and MEK inhibitors
2021
Christos Adamopoulos
Tamer A. Ahmed
Maxwell R. Tucker
Peter M. U. Ung
Min Xiao
Zoi Karoulia
Xuewei Wu
Stuart A. Aaronson
Celina Ang
Vito W. Rebecca
Avner Schlessinger
Meenhard Herlyn
Qi Wang
David E. Shaw
Poulikos I. Poulikakos
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A structural model of a Ras-Raf signalosome
2020
bioRxiv
Venkatesh P. Mysore
Zhi Wei Zhou
Chiara Ambrogio
Lianbo Li
Jonas N. Kapp
Chunya Lu
Qi Wang
Maxwell R. Tucker
Jeffrey J. Okoro
Gabriela Nagy-Davidescu
Xiao Chen Bai
Andreas Plückthun
Pasi A. Jänne
Kenneth D. Westover
Yibing Shan
David E. Shaw
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Citations (9)
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