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Emil R. Unanue

Washington University in St. Louis

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Blood leukocytes recapitulate diabetogenic peptide-MHC-II complexes displayed in the pancreatic islets.

2021 Journal of Experimental Medicine
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The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

2020 Nature Immunology
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Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice.

2020 Proceedings of the National Academy of Sciences of the United States of America
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Citations (5)
The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity

2019 Diabetes
- Emil R. Unanue
- Xiaoxiao Wan
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MHC-II neoantigens shape tumour immunity and response to immunotherapy

2019
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Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset

2019 Science immunology
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Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

2018 Nature
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Identification of Cross Reactive Insulin Immunogenic Epitopes from Commensal Gut Microbes

2018 Diabetes
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The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles

2018 Diabetologia
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Type I and II Interferon Receptors Differentially Regulate Type 1 Diabetes Susceptibility in Male Versus Female NOD Mice

2018 Diabetes
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