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M van Lohuizen

Netherlands Cancer Institute

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EZH2 inhibition sensitizes BRCA1-deficient breast cancer cells to synthetic lethal therapy with ATM inhibitors

2021
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Dual inhibition of EZH2 and ATM displays synergistic cytotoxicity in BRCA1-deficient breast cancers

2020
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Eine EZH2-Inhibition sensitiviert BRCA1-defiziente Mammakarzinome gegenüber einer Therapie mit dem PI3K-Inhibitor BKM120

2017
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Combination therapy of the EZH2 inhibitor GSK126 and the PARP inhibitor Olaparib shows in vivo synergy in a patient-derived xenograft model of BRCA1-deficient breast cancer

2014 Geburtshilfe Und Frauenheilkunde
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374 New tools to evaluate genetic targets and therapeutic strategies against cancer: in vivo imaging and inducible systems to modify gene function

2010 Ejc Supplements
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The Bmi1 polycomb gene as a target for therapies against retinal degeneration

2009 Acta Ophthalmologica
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336 Identification of cancer genes and their collaborative networks by large-scale mutagenesis in tumour prone mice

2009 Ejc Supplements
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In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation

2008 Oncogene
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New Insights Into Photoreceptor Survival Due to Bmi1 Deletion

2007 Investigative Ophthalmology & Visual Science
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The polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens

2006 British Journal of Cancer
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