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Magda Kosmopoulou

Institute of Cancer Research

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Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases

2019 FEBS Journal
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Cyclobutanone Mimics of Intermediates in Metallo-beta-Lactamase Catalysis.

2018 Chemistry: A European Journal
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Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

2016 Proceedings of the National Academy of Sciences of the United States of America
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Citations (77)
Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases

2015 Biochemistry
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Crystal Structure of DIM-1, an Acquired Subclass B1 Metallo-β-Lactamase from Pseudomonas stutzeri

2015 PLOS ONE
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7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives for Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent.

2015 Bioorganic & Medicinal Chemistry Letters
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Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime

2015
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Crystal structure of the metallo-beta-lactamase NDM-1 in complex with a bisthiazolidine inhibitor

2014
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Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells.

2013 Journal of Medicinal Chemistry
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Aurora A kinase bound to a highly selective imidazopyridine inhibitor

2013
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