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Paul Faulder

AstraZeneca

9

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213

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9 (vol 7, pg 1580, 2016)

2016
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Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.

2015 Journal of Medicinal Chemistry
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The crystal structure of H-Ras and SOS in complex with ligands

2015
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Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation

2014 Chemical Communications
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Diverse heterocyclic scaffolds as allosteric inhibitors of AKT.

2012 Journal of Medicinal Chemistry
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Coumarin-based inhibitors of human NAD(P)H:Quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity

2007 Journal of Medicinal Chemistry
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