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Robert J. Nichols

University of California, San Francisco

28

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Abstract 1261: A next generation tri-complex KRASG12C(ON) inhibitor directly targets the active, GTP-bound state of mutant RAS and may overcome resistance to KRASG12C(OFF) inhibition

2021
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Abstract 2837: Dual inhibition of SHP2 and CDK4/6 leads to immunological memory and immune-mediated anti-tumor activity in a mouse syngeneic model of breast cancer

2020 Tumor Biology
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CryoEM structure of the apo-SrpI encapasulin complex from Synechococcus elongatus PCC 7942

2020
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Allosteric inhibition of SHP2 stimulates anti-tumor immunity by transforming the immunosuppressive environment.

2020 Cancer Research
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Abstract 1943: SHP2 inhibition as the backbone of targeted therapy combinations for the treatment of cancers driven by oncogenic mutations in the RAS pathway

2020
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A06 Tri-complex Inhibitors of the Oncogenic, GTP-Bound Form of KRASG12C Overcome RTK-Mediated Escape Mechanisms and Drive Tumor Regressions in Preclinical Models of NSCLC

2020 Journal of Thoracic Oncology
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Abstract LB-113: Positioning a selective, bi-steric inhibitor of mTORC1 as a combination partner in RAS-driven cancers

2020
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A12 The SHP2 Inhibitor RMC-4630 in Patients with KRAS-Mutant Non-Small Cell Lung Cancer: Preliminary Evaluation of a First-in-Man Phase 1 Clinical Trial

2020 Journal of Thoracic Oncology
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Matrix Linear Models for High-Throughput Chemical Genetic Screens

2019 Genetics
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Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins

2019 Cancer Research
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