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Jessica Schmitt

Institute of Cancer Research

19

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Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)

2018 Journal of Medicinal Chemistry
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Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.

2016 Journal of Medicinal Chemistry
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Abstract 3642: Structure enabled design of inhibitors of the mitotic kinase MPS1

2015 Cancer Research
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Abstract 5450: Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug-resistance

2015 Cancer Research
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Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance

2015 Cancer Research
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PKA-S6K1 Chimera with Staurosporine bound

2013
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Structure-based design of orally bioavailable pyrrolopyridine inhibitors of the mitotic kinase MPS1

2013
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Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).

2013 Journal of Medicinal Chemistry
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PKA-S6K1 Chimera with compound 15e (CCT147581) bound

2013
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Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells.

2013 Journal of Medicinal Chemistry
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Citations (46)