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Jonathan Pollock

University of Michigan

17

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430

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Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction.

2020 European Journal of Medicinal Chemistry
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Menin in complex with MI-853

2018
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Menin in complex with MI-1481

2018
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PROCÉDÉS ET COMPOSITIONS D'INHIBITION DE L'INTERACTION DE LA MÉNINE AVEC LES PROTÉINES MLL

2018
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Abstract 3898: Structure-based optimization of small molecule inhibitors of the protein-protein interaction between menin and mixed lineage leukemia (MLL)

2016 Cancer Research
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Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).

2016 Journal of Medicinal Chemistry
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Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

2015 Cancer Cell
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Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes.

2015 Journal of Medicinal Chemistry
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High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

2014 Journal of Medicinal Chemistry
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The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.

2014 Blood
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