author-photo

Paul G. Heyworth

Scripps Research Institute

52

Papers

3400

Citations

Citation Trend

Filter By

Papers (36) Sort By

Journal Conference Others

Absolute requirement for GTP in activation of human neutrophil NADPH oxidase in a cell-free system: Role of ATP in regenerating GTP (superoxide/phagocyte/respiratory burst/oxygen radical/GTP-binding protein)

2016
Show All
- Source
- Cite
- Save
Citations (0)
arising in theNCF-1 pseudogenes in NCF-1, the gene encoding the phagocyte p47-phox: mutations not Autosomal recessive chronic granulomatous disease caused by defects

2013
Show All
- Source
- Cite
- Save
Citations (0)
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice

2011 Journal of Clinical Investigation
Show All
- Source
- Cite
- Save
Citations (46)
Systemicinflammatoryresponsesyndrome(SIRS)isapotentiallylethalcondition,asitcanprogressto shock,multi-organfailure,anddeath.Itcanbetriggeredbyinfection,tissuedamage,orhemorrhage.The roleoftissueinjuryintheprogressionfromSIRStoshockisincompletelyunderstood.Here,weshowthat treatmentofmicewithconcanavalinA(ConA)toinduceliverinjurytriggeredaG-CSF-dependenthepatic infiltrationofCD11b + Gr-1 + Ly6G + Ly6C + immaturemyeloidcellsthatexpressedtheorphanreceptormyeloid DAP12-associatedlectin-1(MDL-1;alsoknownasCLEC5A).ActivationofMDL-1usingdenguevirusoran agonistMDL-1-specificantibodyintheConA-treatedmiceresultedinshock.TheMDL-1 + cellswerepatho- genic,andinvivodepletionofMDL-1 + cellsprovidedprotection.TriggeringMDL-1onthesecellsinduced

2011
Show All
- Source
- Cite
- Save
Citations (0)
Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis

2010 Journal of Experimental Medicine
Show All
- Source
- Cite
- Save
Citations (61)
Focus on FOCIS: The continuing diagnostic challenge of autosomal recessive chronic granulomatous disease

2008 Clinical Immunology
Show All
- Source
- Cite
- Save
Citations (16)
MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis

2007 Journal of Experimental Medicine
Show All
- Source
- Cite
- Save
Citations (561)
Molecular Diagnosis of Chronic Granulomatous Disease

2006
- Paul G. Heyworth
- John T. Curnutte
Show All
- Source
- Cite
- Save
Citations (3)
Unusual polyclonal anti‐gp91phox peptide antibody interactions with X‐linked chronic granulomatous disease‐derived human neutrophils are not from compensatory expression of Nox proteins 1, 3, or 4

2005 European Journal of Haematology
Show All
- Source
- Cite
- Save
Citations (3)
Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox.

2005 European Journal of Haematology
Show All
- Source
- Cite
- Save
Citations (5)