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Matthew P. Epplin

Emory University

9

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The Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-D-Aspartate (NMDA) Receptor.

2020 Journal of Medicinal Chemistry
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Negative allosteric modulation of GluN1/GluN3 NMDA receptors.

2020 Neuropharmacology
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Biased modulators of NMDA receptors control channel opening and ion selectivity

2020 Nature Chemical Biology
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Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors

2020 ACS Chemical Neuroscience
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The bioactive protein-ligand conformation of GluN2C-selective positive allosteric modulators bound to the NMDA receptor

2018 Molecular Pharmacology
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Author response: An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

2018 eLife
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The Structure–Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors

2017 Journal of Medicinal Chemistry
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CHAPTER 13:Mechanism of Action of a GluN2C- and GluN2D-Selective NMDA Receptor Positive Allosteric Modulator

2016
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