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Michael Carter

Institute of Cancer Research

5

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Privileged Structures and Polypharmacology within and between Protein Families

2018 ACS Medicinal Chemistry Letters
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Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)

2018 Journal of Medicinal Chemistry
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Abstract 193: Inhibitors of MPS1: Discovery of CCT289346, a highly potent, selective and orally available preclinical candidate

2017 Cancer Research
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On the origins of three-dimensionality in drug-like molecules.

2016 Future Medicinal Chemistry
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