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Keith J. Miller

Bristol-Myers Squibb

19

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1251

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Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT2C Receptor Agonists

2017 Journal of Medicinal Chemistry
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Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119.

2014 Journal of Medicinal Chemistry
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Synthesis and structure–activity relationship of dihydrobenzofuran derivatives as novel human GPR119 agonists

2014 Bioorganic & Medicinal Chemistry Letters
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Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT2C receptor agonists

2013 Bioorganic & Medicinal Chemistry Letters
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Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.

2013 Bioorganic & Medicinal Chemistry Letters
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Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.

2010 Bioorganic & Medicinal Chemistry Letters
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Position 5.46 of the Serotonin 5-HT2A Receptor Contributes to a Species-Dependent Variation for the 5-HT2C Agonist (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: Impact on Selectivity and Toxicological Evaluation

2009 Molecular Pharmacology
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Discovery of (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a Selective, Orally Active Agonist of the 5-HT2C Receptor

2007 Journal of Medicinal Chemistry
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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

2006 Journal of Pharmacology and Experimental Therapeutics
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Central G-Protein Coupled Receptors (GPCR)s as molecular targets for the treatment of obesity: assets, liabilities and development status.

2004 Current Drug Targets - Cns & Neurological Disorders
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Citations (15)