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Steve Tam

Pfizer

41

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Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).

2012 Bioorganic & Medicinal Chemistry Letters
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Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.

2011 Bioorganic & Medicinal Chemistry Letters
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Discovery of 2-[1-(4-Chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic Acid (PSI-421), a P-Selectin Inhibitor with Improved Pharmacokinetic Properties and Oral Efficacy in Models of Vascular Injury

2010 Journal of Medicinal Chemistry
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Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults.

2010 The Journal of Allergy and Clinical Immunology
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Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice

2010 Arthritis & Rheumatism
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Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties

2009 Bioorganic & Medicinal Chemistry
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089 SELECTIVE AGGRECANASE INHIBITION IS DISEASE MODIFYING AND PAIN ALLEVIATING IN A RAT MENISCAL TEAR MODEL OF OSTEOARTHRITIS

2009 Osteoarthritis and Cartilage
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Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A2α Inhibitors∥

2009 Journal of Medicinal Chemistry
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A Selective Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Chronic Obstructive Pulmonary Disease (COPD): Discovery of (S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408)

2009 Journal of Medicinal Chemistry
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3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: Optimization of selectivity and reduction of protein binding

2009 Bioorganic & Medicinal Chemistry Letters
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Citations (10)