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John L. Humes

Merck & Co.

79

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3206

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Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.

2005 Bioorganic & Medicinal Chemistry Letters
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Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.

2004 Bioorganic & Medicinal Chemistry Letters
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Evaluation of Pyrrolidin-2-imines and 1,3-Thiazolidin-2-imines as Inhibitors of Nitric Oxide Synthase.

2004 ChemInform
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Inhibition of nitric oxide synthase by benzoxazolones

1997 Bioorganic & Medicinal Chemistry Letters
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Inhibition of Neutrophil Elastase in CF Sputum by L-658,758

1997 Journal of Pharmacology and Experimental Therapeutics
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28-kDa mammalian heat shock protein, a novel substrate of a growth regulatory protease involved in differentiation of human leukemia cells.

1995 Journal of Biological Chemistry
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Formation of polymorphonuclear leukocyte elastase: α1 proteinase inhibitor complex and Aα(1–21) fibrinopeptide in human blood stimulated with the calcium ionophore A23187: A model to characterize inhibitors of polymorphonuclear leukocyte elastase

1995 Biochemical Pharmacology
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Intra-peritoneal free elastase in CAPD peritonitis

1993 Kidney International
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Novel substituted azetidinone useful as anti-inflammatory and antidegenerative agents

1992
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New substituted azetidinone useful as intermediate for synthesis

1992
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