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Jing Chen Xiao

Merck & Co.

13

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349

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In Vitro Hollow-Fiber Studies Assessing Antibacterial Activity of Ceftolozane/Tazobactam Against Multidrug-Resistant Pseudomonas Aeruginosa

2020 Open Forum Infectious Diseases
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Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: Synthesis, SAR and biological evaluation

2010 Bioorganic & Medicinal Chemistry Letters
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Discovery of N-[(4R)-6-(4-Chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a Novel Cannabinoid-1 Receptor (CB1R) Inverse Agonist for the Treatment of Obesity

2010 Journal of Medicinal Chemistry
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Pharmacological efficacy and safety profile of taranabant in preclinical species

2009 Drug Development Research
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Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation

2009 Bioorganic & Medicinal Chemistry Letters
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Similar in vitro pharmacology of human cannabinoid CB1 receptor variants expressed in CHO cells.

2008 Brain Research
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Conformational Analysis and Receptor Docking of N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (Taranabant, MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist

2008 Journal of Medicinal Chemistry
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Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists.

2007 Bioorganic & Medicinal Chemistry Letters
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Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

2006 Journal of Medicinal Chemistry
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Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists.

2006 Bioorganic & Medicinal Chemistry Letters
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Citations (24)