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Vered Klinghofer

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Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors

2012 Bioorganic & Medicinal Chemistry Letters
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Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of (S)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor

2010 Journal of Medicinal Chemistry
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Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

2008 Bioorganic & Medicinal Chemistry
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Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.

2008 Molecular Cancer Research
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Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent

2008 Bioorganic & Medicinal Chemistry Letters
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Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling.

2008 Bioorganic & Medicinal Chemistry Letters
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PKA structures of AKT, indazole-pyridine inhibitors

2007
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PKA structures of indazole-pyridine series of AKT inhibitors

2007
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Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.

2007 Bioorganic & Medicinal Chemistry
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Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.

2006 Bioorganic & Medicinal Chemistry Letters
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Citations (36)