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Sebastian M.B. Nijman

Austrian Academy of Sciences

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Abstract 931: From bench to bedside: Using ProTide chemistry to transform 3'-deoxyadenosine into the novel anti-cancer agent Nuc-7738

2021
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Perturbation-Driven Entropy as a Source of Cancer Cell Heterogeneity

2020 Trends in cancer
- Sebastian M.B. Nijman
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Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway.

2020 Science Signaling
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Abstract PR14: MEK inhibitors block growth of Ataxia Telangiectasia Mutated (ATM) mutant lung tumors

2017 Molecular Cancer Therapeutics
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Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells

2017 Nature Chemical Biology
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Discovery of a highly selective cell-active inhibitor of the histone lysine demethylases KDM2/7

2017 Angewandte Chemie
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MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated

2016 Nature Communications
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Parallel reverse genetic screening in mutant human cells using transcriptomics

2016 Molecular Systems Biology
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Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

2016 PLOS Genetics
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NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.

2015 Oncogene
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